CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development
CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development
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CAF-1 在果蝇发育过程中通过靶基因表达的表观遗传控制促进 Notch 信号传导
DOI：
10.1242/dev.094599
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发表时间：
2013-09
期刊：
影响因子：
4.6
通讯作者：
Jiao, Renjie
中科院分区：
文献类型：
--
作者：
Yu, Zhongsheng;Wu, Honggang;Chen, Hanqing;Wang, Ruoqi;Liang, Xuehong;Liu, Jiyong;Li, Changqing;Deng, Wu-Min;Jiao, Renjie
The histone chaperone CAF-1 is known for its role in DNA replication-coupled histone deposition. However, loss of function causes lethality only in higher multicellular organisms such as mice and flies, but not in unicellular organisms such as yeasts, suggesting that CAF-1 has other important functions than histone deposition during animal development. Emerging evidence indicates that CAF-1 also has a role in higher order chromatin organization and heterochromatin-mediated gene expression; it remains unclear whether CAF-1 has a role in specific signaling cascades to promote gene expression during development. Here, we report that knockdown of one of the subunits of Drosophila CAF-1, dCAF-1-p105 (Caf1-105), results in phenotypes that resemble those of, and are augmented synergistically by, mutations of Notch positive regulatory pathway components. Depletion of dCAF-1-p105 leads to abrogation of cut expression and to downregulation of other Notch target genes in wing imaginal discs. dCAF-1-p105 is associated with Suppressor of Hairless [Su(H)] and regulates its binding to the enhancer region of E(spl)mβ. The association of dCAF-1-p105 with Su(H) on chromatin establishes an active local chromatin status for transcription by maintaining a high level of histone H4 acetylation. In response to induced Notch activation, dCAF-1 associates with the Notch intracellular domain to activate the expression of Notch target genes in cultured S2 cells, manifesting the role of dCAF-1 in Notch signaling. Together, our results reveal a novel epigenetic function of dCAF-1 in promoting Notch pathway activity that regulates normal Drosophila development.
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影响因子：
2.7
作者：
Yanjun Song;Feng He;Gengqiang Xie;Xiaoyan Guo;Yanjuan Xu;Yixu Chen;Xuehong Liang;I. Stagljar
通讯作者：
Yanjun Song;Feng He;Gengqiang Xie;Xiaoyan Guo;Yanjuan Xu;Yixu Chen;Xuehong Liang;I. Stagljar
影响因子：
3.7
作者：
Xie G;Zhang H;Du G;Huang Q;Liang X;Ma J;Jiao R
通讯作者：
Jiao R
影响因子：
64.5
作者：
Nakano S;Stillman B;Horvitz HR
通讯作者：
Horvitz HR
影响因子：
16
作者：
Mulligan P;Yang F;Di Stefano L;Ji JY;Ouyang J;Nishikawa JL;Toiber D;Kulkarni M;Wang Q;Najafi-Shoushtari SH;Mostoslavsky R;Gygi SP;Gill G;Dyson NJ;Näär AM
通讯作者：
Näär AM
dRecQ4 是 DNA 合成所必需的，也是果蝇细胞增殖所必需的
影响因子：
3.7
作者：
Xu Y;Lei Z;Huang H;Dui W;Liang X;Ma J;Jiao R
通讯作者：
Jiao R