The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma.
The combination of preoperative platelet count and neutrophil lymphocyte ratio as a prognostic indicator in localized renal cell carcinoma.
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DOI：
10.18632/oncotarget.22688
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发表时间：
2017-12-15
期刊：
影响因子：
--
通讯作者：
Azuma H
中科院分区：
文献类型：
--
作者：
Tsujino T;Komura K;Ichihashi A;Tsutsumi T;Matsunaga T;Yoshikawa Y;Maenosono R;Okita K;Takai T;Oide R;Minami K;Uehara H;Taniguchi K;Hirano H;Nomi H;Ibuki N;Takahara K;Inamoto T;Azuma H
血小板计数和中性粒细胞与淋巴细胞比率（COP-NLR）的组合已被证明可以提供多种癌症的预后信息，而其在肾细胞癌（RCC）中的预后价值尚未报道。本研究的目的是检查COP-NLR在接受肾切除术的局限性RCC患者中的术前预后价值。本文分析了我院268例肾细胞癌患者的临床资料。通过受试者工作特征（ROC）分析和曲线下面积（AUC）确定血小板计数和NLR的临界值。血小板计数升高（> 310×109/l）和NLR升高（> 3.85）的患者被分配为2分，这些指标中有一个或没有的患者分别被分配为1分或0分。采用单变量和多变量考克斯回归分析评价COP-NLR和其他临床病理特征对总生存期（OS）和无复发生存期（RFS）的影响。手术切除后的中位随访时间为60个月。使用单变量分析选择的10个临床病理学结果进行的多变量分析表明，术前COP-NLR是OS（HR：2.32，95%CI：1.22至4.26，p=0.011）和RFS（HR：1.91，95%CI：1.02至3.53，p=0.044）的独立预后因素。本研究的结果表明，术前COP-NLR是局限性RCC患者OS和RFS的独立预后指标。
The combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy. The record of 268 patients, who underwent nephrectomy due to a diagnosis of RCC at our institute was analyzed in the study. The cut-off value of platelet count and NLR were defined by receive operating characteristic (ROC) analysis and the areas under the curve (AUC). Patients with both an increased platelet count (> 310×109/l) and an elevated NLR (> 3.85) were assigned to the score 2, and patients with one or neither of these indicators were assigned to the score 1 or 0, respectively. The impact of the COP-NLR and other clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS) were evaluated using the univariate and multivariate Cox regression analysis. The median follow-up duration after surgical resection was 60 months. Multivariate analysis using the 10 clinicopathological findings selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for OS (HR: 2.32, 95%CI: 1.22 to 4.26, p=0.011) and RFS (HR: 1.91, 95%CI: 1.02 to 3.53, p=0.044). The findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of OS and RFS for patients with localized RCC.
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影响因子：
8.8
作者：
Ishizuka M;Nagata H;Takagi K;Iwasaki Y;Kubota K
通讯作者：
Kubota K
DOI：
10.1073/pnas.94.2.663
发表时间：
1997-01-21
影响因子：
11.1
作者：
Mohle, R;Green, D;Rafii, S
通讯作者：
Rafii, S
影响因子：
5.5
作者：
Biffl, WL;Moore, EE;Peterson, VM
通讯作者：
Peterson, VM
影响因子：
6.6
作者：
Adamy, Ari;Chong, Kian Tai;Russo, Paul
通讯作者：
Russo, Paul
影响因子：
2.6
作者：
Nakahira, Mitsuhiko;Sugasawa, Masashi;Kogashiwa, Yasunao
通讯作者：
Kogashiwa, Yasunao