Wnt signaling and the evolution of embryonic posterior development.

Wnt signaling and the evolution of embryonic posterior development.
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DOI:
10.1016/j.cub.2009.01.052
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发表时间:
2009-03-10
期刊:
Current biology : CB
影响因子:
--
通讯作者:
Kimelman D
Kimelman D
中科院分区:
其他
文献类型:
--
作者:
Martin BL;Kimelman D

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在脊椎动物胚胎发生过程中,头部后面的大部分中胚层组织形成于一个祖先群体,该群体从胚胎的后端不断添加肌肉块(体节)。最近的研究较少的节肢动物,面粉甲虫Tribolium和常见的房子蜘蛛,提供的证据表明,这种后生长过程可能是进化保守的,与典型的Wnt信号在脊椎动物和无脊椎动物中发挥关键作用。我们讨论了这些发现以及其他证据表明,控制后生长的遗传网络已经存在于最后的共同祖先的bilateria。我们还强调了其他有趣的共性以及脊椎动物和无脊椎动物的后部生长之间的差异,建议未来的研究领域,并假设这一过程可能有助于动物身体计划的演变。
During vertebrate embryogenesis, most of the mesodermal tissue posterior to the head forms from a progenitor population that continuously adds blocks of muscles (the somites) from the back end of the embryo. Recent work in less commonly studied arthropods, the flour beetle Tribolium and the common house spider, provides evidence suggesting that this posterior growth process might be evolutionarily conserved, with canonical Wnt signaling playing a key role in vertebrates and invertebrates. We discuss these findings as well as other evidence that suggests that the genetic network controlling posterior growth was already present in the last common ancestor of the bilateria. We also highlight other interesting commonalities as well as differences between posterior growth in vertebrates and invertebrates, suggest future areas of research, and hypothesize that this process may facilitate evolution of animal body plans.
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