pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release.
pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release.
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pH触发的癌症靶向聚合物：从细胞外积累到细胞内释放
DOI：
10.1007/s12274-022-5252-z
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发表时间：
2023
期刊：
影响因子：
9.9
通讯作者：
中科院分区：
文献类型：
--
作者：
刺激响应聚合物有望实现靶向递送，改善循环稳定性，并控制治疗和诊断药物的释放。其中pH响应性高分子纳米载体因其在不同体液（如胃、肠、结肠）和胞内细胞器（如内核体、溶酶体、线粒体）中pH值的变化而维持体内平衡，同时在某些病理状态下pH值也有明显的变化，引起了人们的广泛关注。例如，肿瘤的细胞外环境是酸性的，这可以用来驱动选择性递送。在内化过程中，由于大多数纳米载体通过内吞作用进入细胞，其中从内核体到溶酶体的pH从6.5降至5.0，因此开发了pH敏感基团以增强货物释放。本文综述了非共价相互作用和共价相互作用对pH变化的响应，重点介绍了结构-性质关系及其在癌症靶向和内体逃逸中的应用。
Stimuli-responsive polymers are promising to achieve targeted delivery, improved stability during circulation, and controlled release of therapeutic and diagnostic agents. Among them, pH-responsive polymeric nanocarriers have attracted significant attention as pH varies in different body fluids (e.g., stomach, intestine, and colon) and intracellular organelles (e.g., endosome, lysosome, and mitochondria) to maintain homeostasis, while distinctive pH changes are also found in certain pathological states. For example, the extracellular environment of the tumor is acidic, which can be employed to drive selective delivery. During the internalization process, since most nanocarriers enter cells upon endocytosis where a drop of pH from 6.5 to 5.0 can occur from endosome to lysosome, pH-sensitive groups have been developed for enhanced cargo release. In this review, both non-covalent and covalent interactions responsive to pH changes are introduced, with a focus on the structure-property relationship and their applications in cancer targeting and endosomal escape.
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利用肿瘤微环境增强抗癌治疗的纳米颗粒设计策略
影响因子：
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作者：
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DOI：
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