Zebrafish: a model for the study of addiction genetics.
Zebrafish: a model for the study of addiction genetics.
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DOI：
10.1007/s00439-011-1128-0
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发表时间：
2012-06
期刊：
影响因子：
5.3
通讯作者：
Ekker SC
中科院分区：
文献类型：
--
作者：
Klee EW;Schneider H;Clark KJ;Cousin MA;Ebbert JO;Hooten WM;Karpyak VM;Warner DO;Ekker SC
药物滥用和依赖是多方面的疾病，有着复杂的遗传基础。确定特定的遗传相关是具有挑战性的，通过定义成瘾障碍特有的内表型可能更容易完成。症状和症状，包括急性药物反应、消费、偏爱和戒断，是潜在的表征成瘾的内表型，已经使用模式生物进行了研究。我们介绍了涉及5-羟色胺能、多巴胺能、GABA能和肾上腺素受体信号的主要基因，这些基因被认为直接参与尼古丁、阿片、大麻和乙醇的使用和依赖。斑马鱼的基因组编码了绝大多数这些基因座的可能同源基因。我们还回顾了已知的这些基因在斑马鱼中的表达模式。这篇综述中提供的信息支持使用斑马鱼作为研究与药物成瘾有关的遗传因素的可行模型。利用模型生物扩大对药物反应的研究，有可能促进我们对人类药物反应和成瘾的理解。
Drug abuse and dependence are multifaceted disorders with complex genetic underpinnings. Identifying specific genetic correlates is challenging and may be more readily accomplished by defining endophenotypes specific for addictive disorders. Symptoms and syndromes, including acute drug response, consumption, preference, and withdrawal, are potential endophenotypes characterizing addiction that have been investigated using model organisms. We present a review of major genes involved in serotonergic, dopaminergic, GABAergic, and adrenoreceptor signaling that are considered to be directly involved in nicotine, opioid, cannabinoid, and ethanol use and dependence. The zebrafish genome encodes likely homologs of the vast majority of these loci. We also review the known expression patterns of these genes in zebrafish. The information presented in this review provides support for the use of zebrafish as a viable model for studying genetic factors related to drug addiction. Expansion of investigations into drug response using model organisms holds the potential to advance our understanding of drug response and addiction in humans.
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