Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition, Analysis, and Examples.
Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition, Analysis, and Examples.
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动态对比增强了肿瘤学中的磁共振成像：理论，数据采集，分析和示例。
DOI：
10.2174/157340507780619179
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发表时间：
2009-05-01
影响因子：
--
通讯作者：
Gore JC
中科院分区：
文献类型：
--
作者：
Yankeelov TE;Gore JC
Dynamic contrast enhanced MRI (DCE-MRI) enables the quantitative assessment of tumor status and has found application in both pre-clinical tumor models as well as clinical oncology. DCE-MRI requires the serial acquisition of images before and after the injection of a paramagnetic contrast agent so that the variation of MR signal intensity with time can be recorded for each image voxel. As the agent enters into a tissue, it changes the MR signal intensity from the tissue to a degree that depends on the local concentration. After the agent is transported out of the tissue, the MR signal intensity returns to its’ baseline value. By analyzing the associated signal intensity time course using an appropriate mathematical model, physiological parameters related to blood flow, vessel permeability, and tissue volume fractions can be extracted for each voxel or region of interest. In this review we first discuss the basic physics of this methodology, and then present technical aspects of how DCE-MRI data are acquired and analyzed. We also discuss appropriate models of contrast agent kinetics and how these can be used to elucidate tissue characteristics of importance in cancer biology. We conclude by briefly summarizing some future goals and demands of DCE-MRI.
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影响因子：
8.4
作者：
de Lussanet, QG;Beets-Tan, RGH;Griffioen, AW
通讯作者：
Griffioen, AW
影响因子：
3.3
作者：
Brasch, R;Turetschek, K
通讯作者：
Turetschek, K
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3.8
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Chen, WJ;Giger, ML;Bick, U
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Bick, U
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3.3
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Cao, Y;Brown, SL;Ewing, JR
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Ewing, JR
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3.3
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DONAHUE, KM;WEISSKOFF, RM;ROSEN, BR
通讯作者：
ROSEN, BR