Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice.
Short-term environmental enrichment enhances adult neurogenesis, vascular network and dendritic complexity in the hippocampus of type 1 diabetic mice.
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DOI：
10.1371/journal.pone.0013993
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发表时间：
2010-11-15
期刊：
影响因子：
3.7
通讯作者：
Saravia F
中科院分区：
文献类型：
--
作者：
Beauquis J;Roig P;De Nicola AF;Saravia F
已经描述了与人类1型糖尿病相关的几种脑紊乱。在动物模型中，海马病理变化与认知缺陷一起报告。在一定时间内暴露于各种环境刺激能够防止大脑改变，并在压力，衰老和神经退行性过程等条件下改善学习和记忆。我们探讨了丰富环境对链脲佐菌素诱导的1型糖尿病小鼠海马改变的调节作用。在标准条件下饲养的糖尿病小鼠中，我们发现与相同饲养条件下的对照动物相比，齿状回中成年神经发生减少，CA 1神经元树突复杂性降低，齿状回中血管分数面积较小。短时间暴露-10天-丰富的环境能够提高增殖，存活和树突状分支的新生神经元，恢复树突状树的长度和棘密度的锥体CA 1神经元和增加糖尿病动物的齿状回的血管网络。环境的复杂性似乎构成了一个强大的刺激器有能力拯救糖尿病大脑神经退行性疾病的进展。
Several brain disturbances have been described in association to type 1 diabetes in humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure to a variety of environmental stimuli during a certain period of time is able to prevent brain alterations and to improve learning and memory in conditions like stress, aging and neurodegenerative processes. We explored the modulation of hippocampal alterations in streptozotocin-induced type 1 diabetic mice by environmental enrichment. In diabetic mice housed in standard conditions we found a reduction of adult neurogenesis in the dentate gyrus, decreased dendritic complexity in CA1 neurons and a smaller vascular fractional area in the dentate gyrus, compared with control animals in the same housing condition. A short exposure -10 days- to an enriched environment was able to enhance proliferation, survival and dendritic arborization of newborn neurons, to recover dendritic tree length and spine density of pyramidal CA1 neurons and to increase the vascular network of the dentate gyrus in diabetic animals. The environmental complexity seems to constitute a strong stimulator competent to rescue the diabetic brain from neurodegenerative progression.
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影响因子：
3.4
作者：
Couillard-Despres, S;Winner, B;Aigner, L
通讯作者：
Aigner, L
影响因子：
5.3
作者：
Beauquis, Juan;Homo-Delarche, Francoise;Saravia, Flavia
通讯作者：
Saravia, Flavia
影响因子：
4.2
作者：
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通讯作者：
Potter, Huntington
DOI：
10.1073/pnas.2234031100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Ekdahl, CT;Claasen, JH;Lindvall, O
通讯作者：
Lindvall, O
影响因子：
2.5
作者：
Ekstrand, Joakim;Hellsten, Johan;Tingstrom, Anders
通讯作者：
Tingstrom, Anders