Central Feminization of Obese Male Mice Reduces Metabolic Syndrome.
Central Feminization of Obese Male Mice Reduces Metabolic Syndrome.
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DOI：
10.3390/brainsci12101324
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发表时间：
2022-09-30
期刊：
影响因子：
3.3
通讯作者：
Young, Colin N.
中科院分区：
文献类型：
--
作者：
Blackmore, Katherine;Young, Colin N.
代谢综合征包括一系列增加心血管和代谢疾病风险的病症。人们普遍认为，性激素雌激素在绝经前女性中发挥着保护性代谢作用，部分是通过中枢神经系统（CNS）机制实现的。然而，迄今为止，大多数工作都集中在女性雌激素的丧失（例如更年期）上。有趣的是，接受女性化性别肯定疗法（即雌激素）的跨性别者相对免受代谢综合征的影响，这表明中枢神经系统雌激素在男性代谢综合征的发展中发挥着作用。在这里，我们证明大脑中的雌激素信号可以保护男性免受代谢综合征和肥胖相关并发症的影响。首先，在饮食诱导的肥胖雄性小鼠中短期中枢神经系统特异性补充低剂量17-β-雌二醇可导致体重显着减轻，同时食物摄入量减少，但能量消耗没有改变。同时，集中补充雌激素可减少内脏肥胖，包括附睾和腹部区域，皮下腹股沟和产热棕色脂肪组织略有减少。此外，中枢雌激素给药减少了代谢综合征的肝脏表现，包括肝肿大和肝脂肪变性。总的来说，这些发现表明，大脑中雌激素作用的缺乏可能使男性容易患代谢综合征的发病机制。
Metabolic syndrome encompasses a spectrum of conditions that increases the risk for cardiovascular and metabolic diseases. It is widely accepted that the sex hormone estrogen plays a protective metabolic role in premenopausal women, in part through central nervous system (CNS) mechanisms. However, most work to date has focused on the loss of estrogen in females (e.g., menopause). Interestingly, transgender individuals receiving feminizing gender affirming therapy (i.e., estrogen) are relatively protected from metabolic syndrome conditions, pointing to a role for CNS estrogen in the development of metabolic syndrome in men. Here, we show that estrogen signaling in the brain protects males from metabolic syndrome and obesity related complications. First, short-term CNS specific supplementation of low-dose 17-β-estradiol in diet-induced obese male mice resulted in a significant reduction in body weight in parallel with a decrease in food intake without alterations in energy expenditure. In conjunction, central supplementation of estrogen reduced visceral adiposity, including epididymal and abdominal regions, with slighter decreases in subcutaneous inguinal and thermogenic brown adipose tissue. Furthermore, central estrogen administration reduced the liver manifestation of metabolic syndrome including hepatomegaly and hepatic steatosis. Collectively, these findings indicate that a lack of estrogen action in the brain may predispose males to metabolic syndrome pathogenesis.
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