The Tumor Microenvironment in Cholangiocarcinoma Progression.
The Tumor Microenvironment in Cholangiocarcinoma Progression.
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DOI：
10.1002/hep.31410
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Strazzabosco M
中科院分区：
文献类型：
--
作者：
Fabris L;Sato K;Alpini G;Strazzabosco M
胆管癌是一种侵袭性的异质性胆道恶性肿瘤。CCA的一个典型标志是癌细胞嵌入含有纤维化细胞、胶质细胞和各种免疫细胞的致密基质中。反应性肿瘤间质的功能作用尚未完全阐明;然而，最近的研究表明，肿瘤微环境在CCA的进展和侵袭性中起着关键作用。CCA细胞与其他癌细胞和填充微环境的浸润细胞类型交换自分泌/旁分泌信号。这种串扰受各种细胞因子、趋化因子和生长因子介导的信号控制。此外，细胞外囊泡（EV）、外泌体和微囊泡，含有货物介质，如蛋白质和RNA，在细胞间通讯中起关键作用，特别是在表观遗传调控中，这要归功于它们在miRNA中的含量。CCA细胞和其他肝细胞之间的细胞因子和EV介导的通信为CCA的管理提供了潜在的新靶点。本文综述了CCA中肿瘤微环境和细胞间通讯及其在肿瘤进展中的作用。
Cholangiocarcinoma (CCA) is an aggressive and heterogeneous malignancy of the biliary tree. A typical hallmark of CCA is that cancer cells are embedded into a dense stroma containing fibrogenic cells, lymphatics and a variety of immune cells. Functional roles of the reactive tumor stroma are not fully elucidated; however, recent studies suggest that the tumor microenvironment plays a key role in the progression and invasiveness of CCA. CCA cells exchange autocrine/paracrine signals with other cancer cells and the infiltrating cell types that populate the microenvironment. This crosstalk is under the control of signals mediated by various cytokines, chemokines, and growth factors. In addition, extracellular vesicles (EVs), exosomes and microvesicles, containing cargo mediators, such as proteins and RNAs, play a key role in cell-to-cell communication, and particularly in epigenetic regulation thanks to their content in miRNAs. Both cytokine- and EV-mediated communications between CCA cells and other liver cells provide a potential novel target for the management of CCA. This review summarizes current understandings of the tumor microenvironment and intercellular communications in CCA and their role in tumor progression.
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