The dual nature of interleukin-10 in pemphigus vulgaris.
The dual nature of interleukin-10 in pemphigus vulgaris.
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DOI:
10.1016/j.cyto.2014.11.002
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发表时间:
2015-06
期刊:
影响因子:
3.8
通讯作者:
Payne, Aimee S.
中科院分区:
文献类型:
--
作者:
Cho, Michael Jeffrey;Ellebrecht, Christoph T.;Payne, Aimee S.
The immunomodulatory cytokine interleukin-10 (IL-10) plays beneficial but also potentially detrimental roles in inflammation, infection, and autoimmunity. Recent studies suggest a regulatory role for IL-10-expressing B cells in the autoimmune blistering disease pemphigus vulgaris. Here we review the studies on IL-10 in pemphigus vulgaris and discuss the potential pathophysiological significance of these findings in comparison to prior studies of IL-10 in other human conditions. A better understanding of the complex roles of IL-10 in immune regulation may improve our understanding of pemphigus pathogenesis and treatment.
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