Diazepam effects on local cortical neural activity during sleep in mice.
Diazepam effects on local cortical neural activity during sleep in mice.
复制标题
安定对小鼠睡眠时局部皮质神经活动的影响。
DOI：
10.1016/j.bcp.2021.114515
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发表时间：
2021-09
影响因子：
5.8
通讯作者：
Vyazovskiy VV
中科院分区：
文献类型：
--
作者：
McKillop LE;Fisher SP;Milinski L;Krone LB;Vyazovskiy VV
GABA能神经传递在睡眠调节机制和睡眠期间的脑振荡中起关键作用。已知苯二氮卓类（如地西泮）可诱导镇静并促进睡眠，然而，在给予苯二氮卓类或类似化合物后，慢频率的EEG频谱功率通常会降低。EEG慢波产生于皮层网络活动（ON）和沉默（OFF）周期之间的同步交替，并且代表先前睡眠-觉醒历史的敏感标记。然而，目前尚不清楚苯二氮卓类药物在睡眠期间如何作用于皮层神经活动。为了解决这一问题，我们获得了慢性记录的局部场电位和多单位活动（MUA）从深层皮质层的初级运动皮层在自由行为的小鼠注射安定后。我们发现，个别LFP慢波的幅度显着降低后，地西泮注射，并伴随着较低的发病率和相应的神经元OFF期间的持续时间。进一步的研究表明，这是由于大脑皮层神经元的同步中断。我们的数据表明，全局睡眠和局部皮层同步的状态可以分离，并且苯二氮卓类药物诱导的大脑状态与自发生理睡眠有质的不同。
GABA-ergic neurotransmission plays a key role in sleep regulatory mechanisms and in brain oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation and promote sleep, however, EEG spectral power in slow frequencies is typically reduced after the administration of benzodiazepines or similar compounds. EEG slow waves arise from a synchronous alternation between periods of cortical network activity (ON) and silence (OFF), and represent a sensitive marker of preceding sleep-wake history. Yet it remains unclear how benzodiazepines act on cortical neural activity during sleep. To address this, we obtained chronic recordings of local field potentials and multiunit activity (MUA) from deep cortical layers of the primary motor cortex in freely behaving mice after diazepam injection. We found that the amplitude of individual LFP slow waves was significantly reduced after diazepam injection and was accompanied by a lower incidence and duration of the corresponding neuronal OFF periods. Further investigation suggested that this is due to a disruption in the synchronisation of cortical neurons. Our data suggest that the state of global sleep and local cortical synchrony can be dissociated, and that the brain state induced by benzodiazepines is qualitatively different from spontaneous physiological sleep.
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影响因子：
16.6
作者：
Fisher, Simon P.;Cui, Nanyi;McKillop, Laura E.;Gemignani, Jessica;Bannerman, David M.;Oliver, Peter L.;Peirson, Stuart N.;Vyazovskiy, Vladyslav V.
通讯作者：
Vyazovskiy, Vladyslav V.
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
9.8
作者：
Cirelli C;Tononi G
通讯作者：
Tononi G
影响因子：
4.4
作者：
Deboer, T
通讯作者：
Deboer, T
影响因子：
3.3
作者：
Achermann, P;Borbely, AA
通讯作者：
Borbely, AA