Stereotypic wheel running decreases cortical activity in mice.
Stereotypic wheel running decreases cortical activity in mice.
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DOI：
10.1038/ncomms13138
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发表时间：
2016-10-17
影响因子：
16.6
通讯作者：
Vyazovskiy, Vladyslav V.
中科院分区：
文献类型：
--
作者：
Fisher, Simon P.;Cui, Nanyi;McKillop, Laura E.;Gemignani, Jessica;Bannerman, David M.;Oliver, Peter L.;Peirson, Stuart N.;Vyazovskiy, Vladyslav V.
长时间的清醒被认为会逐渐增加“睡眠需求”，并影响随后的睡眠时间和强度，但具体的清醒行为的作用仍不清楚。在这里，我们报告了清醒状态下自愿跑轮子对小鼠运动和躯体感觉皮层神经元活动的影响。我们发现，刻板的车轮运行与大量的皮质神经元亚群之间的放电率大幅降低，特别是在高速。轮跑也对清醒期间的尖峰活动有长期影响。具体来说，皮质放电率显着较高的自发延长清醒期结束。然而，当清醒状态由转轮活动主导时，这种增加被消除。这些发现表明，唤醒相关的放电率的变化不仅取决于唤醒持续时间，而且还取决于特定的唤醒行为。 睡眠需求被认为是在清醒期间逐渐积累的，并且与神经元活动的变化有关。在这里，作者表明，在小鼠中，皮层放电率在清醒期的开始和结束之间增加，但这种增加在清醒期与自愿刻板的车轮运行中没有看到。
Prolonged wakefulness is thought to gradually increase ‘sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Wheel running also has longer-term effects on spiking activity across periods of wakefulness. Specifically, cortical firing rates are significantly higher towards the end of a spontaneous prolonged waking period. However, this increase is abolished when wakefulness is dominated by running wheel activity. These findings indicate that wake-related changes in firing rates are determined not only by wake duration, but also by specific waking behaviours. Sleep need is thought to accumulate gradually over waking periods and is associated with changes in neuronal activity. Here the authors show that in mice cortical firing rates increase between the beginning and end of wakefulness periods but this increase is not seen in waking periods with voluntary stereotypic wheel running.
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影响因子：
16.2
作者：
Bennett C;Arroyo S;Hestrin S
通讯作者：
Hestrin S
影响因子：
2.7
作者：
Greenwood, Benjamin N.;Foley, Teresa E.;Le, Tony V.;Strong, Paul V.;Loughridge, Alice B.;Day, Heidi E. W.;Fleshner, Monika
通讯作者：
Fleshner, Monika
影响因子：
2.5
作者：
Jackson, Jesse;Ayzenshtat, Inbal;Yuste, Rafael
通讯作者：
Yuste, Rafael
影响因子：
3.3
作者：
Achermann, P;Borbely, AA
通讯作者：
Borbely, AA
影响因子：
2.9
作者：
EDGAR, DM;KILDUFF, TS;DEMENT, WC
通讯作者：
DEMENT, WC