Cancer killers in the human gut microbiota: diverse phylogeny and broad spectra.
Cancer killers in the human gut microbiota: diverse phylogeny and broad spectra.
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人类肠道微生物群中的癌症杀手：不同的系统发育和广谱
DOI：
10.18632/oncotarget.17319
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发表时间：
2017-07-25
期刊：
影响因子：
--
通讯作者：
Liu SL
中科院分区：
文献类型：
--
作者：
Zhou YJ;Zhao DD;Liu H;Chen HT;Li JJ;Mu XQ;Liu Z;Li X;Tang L;Zhao ZY;Wu JH;Cai YX;Huang YZ;Wang PG;Jia YY;Liang PQ;Peng X;Chen SY;Yue ZL;Yuan XY;Lu T;Yao BQ;Li YG;Liu GR;Liu SL
癌症作为一大类复杂的疾病，被认为是众多遗传和环境因素相互作用的结果，但也可能发生在没有任何已知遗传或环境风险的人身上，这表明存在其他强大的因素来影响癌症的发生过程。最近，许多注意力集中在肠道微生物区系的特定成员上，因为它们在促进癌症发生方面具有潜在的作用。在这里，我们报告了肠道细菌的鉴定和特征，这些细菌对广泛的实体癌症和白血病具有强大的抗恶性肿瘤活性。我们采集了不同年龄段的健康人(学龄前儿童和大学生)的粪便标本，检测了它们对癌细胞的作用，并获得了具有较强抗肿瘤活性的细菌。这些细菌主要属于放线杆菌，但也包括其他门的谱系，如变形杆菌和菲尔米库特。在动物癌症模型中，来自细菌的无菌培养上清高效地抑制了肿瘤的生长。值得注意的是，肿瘤内给药的细菌产物防止了转移，甚至清除了远离肿瘤部位的癌细胞。这项工作证明了人类肠道微生物区系中普遍存在着强大的恶性肿瘤杀手，这种微生物可能会在恶性细胞形成癌症之前常规地将它们从体内清除出去。
Cancer as a large group of complex diseases is believed to result from the interactions of numerous genetic and environmental factors but may develop in people without any known genetic or environmental risks, suggesting the existence of other powerful factors to influence the carcinogenesis process. Much attention has been focused recently on particular members of the intestinal microbiota for their potential roles in promoting carcinogenesis. Here we report the identification and characterization of intestinal bacteria that exhibited potent anti-malignancy activities on a broad range of solid cancers and leukemia. We collected fecal specimens from healthy individuals of different age groups (preschool children and university students), inspected their effects on cancer cells, and obtained bacteria with potent anti-malignancy activities. The bacteria mostly belonged to Actinobacteria but also included lineages of other phyla such as Proteobacteria and Firmicutes. In animal cancer models, sterile culture supernatant from the bacteria highly effectively inhibited tumor growth. Remarkably, intra-tumor administration of the bacterial products prevented metastasis and even cleared cancer cells at remote locations from the tumor site. This work demonstrates the prevalent existence of potent malignancy-killers in the human intestinal microbiota, which may routinely clear malignant cells from the body before they form cancers.
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微生物组和癌症。
DOI：
10.1038/nrc3610
发表时间：
2013-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1126/science.1260825
发表时间：
2015-01-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Tomasetti C;Vogelstein B
通讯作者：
Vogelstein B
影响因子：
168.9
作者：
Danaei, G;Vander Hoorn, S;Ezzati, M
通讯作者：
Ezzati, M
通过人体肠道细菌生物转化脱脂亚麻籽生产肠二醇
影响因子：
4.2
作者：
Wang CZ;Ma XQ;Yang DH;Guo ZR;Liu GR;Zhao GX;Tang J;Zhang YN;Ma M;Cai SQ;Ku BS;Liu SL
通讯作者：
Liu SL
影响因子：
10.7
作者：
SAITOU, N;NEI, M
通讯作者：
NEI, M