Rapid evolution of the intersexual genetic correlation for fitness in Drosophila melanogaster.
Rapid evolution of the intersexual genetic correlation for fitness in Drosophila melanogaster.
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DOI：
10.1111/evo.12892
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Reuter M
中科院分区：
文献类型：
--
作者：
Collet JM;Fuentes S;Hesketh J;Hill MS;Innocenti P;Morrow EH;Fowler K;Reuter M
当男性和女性的表型处于相反的选择下，但遗传相关时，就会出现性对抗(SA)。在问题得到解决之前，敌对情绪会限制向最佳性别特定表型的进化。尽管它对特定性别的适应和现有的理论很重要，但从经验上还不能很好地理解SA解决的动态。在这里，我们提供了果蝇的数据，与SA的分辨率兼容。我们比较了先前描述SA的“LHM”种群的两个独立副本。两者都在相同的受控条件下保存，并分开了大约200代人。虽然雄性和雌性适合度的遗传力相似，但两性间的遗传相关存在显著差异，在一个重复中为负(表示SA)，而在另一个重复中接近于零。利用群体测序，我们表明表型差异与基因组中非随机基因座的等位基因频率的群体差异有关。较大的频率变化在没有SA的人群中更为普遍，并在映射到先前显示的在表达和适应性之间具有性别拮抗关系的基因的基因座上得到丰富。我们的数据表明，SA解决方案的快速进化已经发生在一个群体中，并为研究SA及其解决方案的遗传学开辟了道路。
Sexual antagonism (SA) arises when male and female phenotypes are under opposing selection, yet genetically correlated. Until resolved, antagonism limits evolution toward optimal sex‐specific phenotypes. Despite its importance for sex‐specific adaptation and existing theory, the dynamics of SA resolution are not well understood empirically. Here, we present data from Drosophila melanogaster, compatible with a resolution of SA. We compared two independent replicates of the “LHM” population in which SA had previously been described. Both had been maintained under identical, controlled conditions, and separated for around 200 generations. Although heritabilities of male and female fitness were similar, the intersexual genetic correlation differed significantly, being negative in one replicate (indicating SA) but close to zero in the other. Using population sequencing, we show that phenotypic differences were associated with population divergence in allele frequencies at nonrandom loci across the genome. Large frequency changes were more prevalent in the population without SA and were enriched at loci mapping to genes previously shown to have sexually antagonistic relationships between expression and fitness. Our data suggest that rapid evolution toward SA resolution has occurred in one of the populations and open avenues toward studying the genetics of SA and its resolution.
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