Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.
Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.
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从海洋海绵Tethya Aurantium分离的真菌的系统发育鉴定以及其继发代谢产物的鉴定。
DOI：
10.3390/md9040561
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发表时间：
2011
期刊：
影响因子：
5.4
通讯作者：
Imhoff JF
中科院分区：
文献类型：
--
作者：
Wiese J;Ohlendorf B;Blümel M;Schmaljohann R;Imhoff JF
通过形态学标准和基于内部转录间隔区 (ITS) 区域的系统发育分析，分离并鉴定了与海洋海绵 Tethya aurantium 相关的真菌。对它们的次级代谢物谱进行了评估。在已鉴定的 81 个分离株中，鉴定出 21 个属的成员。顶孢霉属、曲霉属、镰刀菌属、青霉属、茎点霉属和木霉属等属相当常见，但我们也从海绵中分离到了葡萄球菌属、附球菌属、副球菌属和三提拉球菌属等很少报道的菌株。在这项研究中，首次从海绵中分离出属于 Bartalinia 属和 Volutella 属以及可能是新的茎点霉属的成员。根据分类，选择菌株来分析其生产天然产物的能力。除了许多已知化合物外，还鉴定了几种新的天然产物。镰孢内酯和山梨呋喃酮已在其他地方描述过。我们分离出了四种迄今为止尚未描述的其他物质。新的代谢物 cillifuranone (1) 是从 Penicillium chrysogenum 菌株 LF066 中分离出来的。基于 1D 和 2D NMR 分析阐明了西利呋喃酮 (1) 的结构，并证明它是先前假设的山梨呋喃酮生物合成中间体。迄今为止，仅发现该化合物具有较小的抗生素生物活性。
Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members of 21 genera were identified. Some genera like Acremonium, Aspergillus, Fusarium, Penicillium, Phoma, and Trichoderma are quite common, but we also isolated strains belonging to genera like Botryosphaeria, Epicoccum, Parasphaeosphaeria, and Tritirachium which have rarely been reported from sponges. Members affiliated to the genera Bartalinia and Volutella as well as to a presumably new Phoma species were first isolated from a sponge in this study. On the basis of their classification, strains were selected for analysis of their ability to produce natural products. In addition to a number of known compounds, several new natural products were identified. The scopularides and sorbifuranones have been described elsewhere. We have isolated four additional substances which have not been described so far. The new metabolite cillifuranone (1) was isolated from Penicillium chrysogenum strain LF066. The structure of cillifuranone (1) was elucidated based on 1D and 2D NMR analysis and turned out to be a previously postulated intermediate in sorbifuranone biosynthesis. Only minor antibiotic bioactivities of this compound were found so far.
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影响因子：
4.4
作者：
Gao, Zheng;Li, Binglin;Wang, Guangyi
通讯作者：
Wang, Guangyi
影响因子：
5.1
作者：
Maskey, RP;Grün-Wollny, I;Laatsch, H
通讯作者：
Laatsch, H
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
3.3
作者：
Helaly, Soleiman;Schneider, Kathrin;Fiedler, Hans-Peter
通讯作者：
Fiedler, Hans-Peter
影响因子：
2.8
作者：
KOHLMEYER, J;VOLKMANNKOHLMEYER, B
通讯作者：
VOLKMANNKOHLMEYER, B