Grid cells and theta as oscillatory interference: theory and predictions.
Grid cells and theta as oscillatory interference: theory and predictions.
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网格细胞和theta作为振荡干扰：理论和预测。
DOI：
10.1002/hipo.20518
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发表时间：
2008
期刊：
影响因子：
3.5
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
--
作者：
Burgess, Neil
振荡干扰模型的网格单元射击的路径集成的算法级描述和作为一个实现级的描述网格单元和它们的输入进行审查。新的分析关注的变量之间的关系，在模型和θ节奏，运行速度和固有的发射频率的网格细胞。新的模拟关注的速度控制振荡器（VCO）的实施与不同的首选方向在不同的神经元。为了总结该模型，沿特定方向沿着行进的距离由VCO相对于基线频率的相位编码。每个VCO都是一种固有的膜电位振荡，其频率由于来自速度调制的头部方向细胞的突触输入的去极化而从基线增加。网格单元激发由VCO驱动，VCO的首选方向与当前运动方向相匹配。VCO通过来自位置单元的位置特定输入进行相位复位，以防止误差累积。基线频率用VCO频率的局部平均值来识别，而EEG θ频率用全局平均VCO频率来识别，并且包括两个分量：零速度下的频率和对运行速度的线性响应。定量预测给出了一个网格细胞的固有的发射频率和网格规模之间的相互关系，θ频率的两个组成部分，和运行速度的动物。定性预测的性质的VCOs，和环境新奇，两个组件的θ，网格规模和位置细胞重映射之间的关系。
The oscillatory interference model of grid cell firing is reviewed as an algorithmic level description of a path integration and as an implementation level description of grid cells and their inputs. New analyses concern the relationships between the variables in the model and the theta rhythm, running speed and the intrinsic firing frequencies of grid cells. New simulations concern the implementation of velocity-controlled oscillators (VCOs) with different preferred directions in different neurons. To summarize the model, the distance travelled along a specific direction is encoded by the phase of a VCO relative to a baseline frequency. Each VCO is an intrinsic membrane potential oscillation whose frequency increases from baseline as a result of depolarisation by synaptic input from speed modulated head-direction cells. Grid cell firing is driven by the VCOs whose preferred directions match the current direction of motion. VCOs are phase-reset by location-specific input from place cells to prevent accumulation of error. The baseline frequency is identified with the local average of VCO frequencies, while EEG theta frequency is identified with the global average VCO frequency and comprises two components: the frequency at zero speed, and a linear response to running speed. Quantitative predictions are given for the inter-relationships between a grid cell’s intrinsic firing frequency and grid scale, the two components of theta frequency, and the running speed of the animal. Qualitative predictions are given for the properties of the VCOs, and relationship between environmental novelty, the two components of theta, grid scale and place cell remapping.
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theta修饰的大鼠海马形成中的划分细胞。
DOI：
10.1523/jneurosci.2635-04.2004
发表时间：
2004-09-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cacucci F;Lever C;Wills TJ;Burgess N;O'Keefe J
通讯作者：
O'Keefe J
影响因子：
1.9
作者：
Burgess, N;Jackson, A;O'Keefe, J
通讯作者：
O'Keefe, J
影响因子：
16.2
作者：
Ekstrom, AD;Meltzer, J;Barnes, CA
通讯作者：
Barnes, CA
影响因子：
1.9
作者：
Cho, JW;Sharp, PE
通讯作者：
Sharp, PE
DOI：
10.1016/0013-4694(79)90033-6
发表时间：
1979-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
BUZSAKI, G;GRASTYAN, E;CZOPF, J
通讯作者：
CZOPF, J