Sensory TRP channels contribute differentially to skin inflammation and persistent itch.
Sensory TRP channels contribute differentially to skin inflammation and persistent itch.
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感觉 TRP 通道对皮肤炎症和持续瘙痒的影响不同
DOI：
10.1038/s41467-017-01056-8
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发表时间：
2017-10-30
影响因子：
16.6
通讯作者：
Hu H
中科院分区：
文献类型：
--
作者：
Feng J;Yang P;Mack MR;Dryn D;Luo J;Gong X;Liu S;Oetjen LK;Zholos AV;Mei Z;Yin S;Kim BS;Hu H
虽然持续性瘙痒和炎症通常与过敏性接触性皮炎（ACD）相关，但尚不清楚它们是否由共享或不同的信号通路介导。在这里，我们表明，TRPA1和TRPV1通道都需要产生自发抓挠在小鼠模型的ACD方酸二丁酯（SADBE），一种小分子半抗原，通过直接促进兴奋性的神经元受体。TRPV1而不是TRPA1通道保护皮肤炎症，因为TRPV1功能的遗传消融或TRPV1阳性感觉神经的药理学消融促进SADBE诱导的ACD中的皮肤炎症。我们的研究结果表明，持续瘙痒和炎症介导的不同的细胞和分子机制在小鼠模型的ACD。识别TRPA1和TRPV1在调节瘙痒和炎症中的不同作用可能为ACD患者慢性瘙痒和炎症的病理生理学和治疗提供新的见解。过敏性接触性皮炎与持续瘙痒和炎症有关，但尚不清楚这些是否由共同的信号通路介导。作者表明，持续性瘙痒需要TRPA1和TRPV1，而TRPV1对小鼠皮肤炎症具有保护作用。
Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SADBE-induced ACD. Our results demonstrate that persistent itch and inflammation are mediated by distinct cellular and molecular mechanisms in a mouse model of ACD. Identification of distinct roles of TRPA1 and TRPV1 in regulating itch and inflammation may provide new insights into the pathophysiology and treatment of chronic itch and inflammation in ACD patients. Allergic contact dermatitis is associated both with persistent itch and inflammation, but it is not known if these are mediated by shared signaling pathways. The authors show that persistent itch requires both TRPA1 and TRPV1, while TRPV1 has a protective role against skin inflammation in mice.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
32.4
作者：
Kashem SW;Riedl MS;Yao C;Honda CN;Vulchanova L;Kaplan DH
通讯作者：
Kaplan DH
DOI：
10.1523/jneurosci.3509-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu Q;Sikand P;Ma C;Tang Z;Han L;Li Z;Sun S;LaMotte RH;Dong X
通讯作者：
Dong X
影响因子：
3.3
作者：
Bánvölgyi, A;Pálinkás, L;Pintér, E
通讯作者：
Pintér, E
影响因子：
6.4
作者：
Beresford, L;Orange, O;Miyan, JA
通讯作者：
Miyan, JA