A novel polymer of tubulin forms the conoid of Toxoplasma gondii.
A novel polymer of tubulin forms the conoid of Toxoplasma gondii.
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DOI：
10.1083/jcb.200112086
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发表时间：
2002-03-18
期刊：
影响因子：
--
通讯作者：
Murray JM
中科院分区：
文献类型：
--
作者：
Hu K;Roos DS;Murray JM
Toxoplasma gondii is an obligatory intracellular parasite, an important human pathogen, and a convenient laboratory model for many other human and veterinary pathogens in the phylum Apicomplexa, such as Plasmodium, Eimeria, and Cryptosporidia. 22 subpellicular microtubules form a scaffold that defines the cell shape of T. gondii. Its cytoskeleton also includes an intricate apical structure consisting of the conoid, two intraconoid microtubules, and two polar rings. The conoid is a 380-nm diameter motile organelle, consisting of fibers wound into a spiral like a compressed spring. FRAP analysis of transgenic T. gondii expressing YFP-α-tubulin reveals that the conoid fibers are assembled by rapid incorporation of tubulin subunits during early, but not late, stages of cell division. Electron microscopic analysis shows that in the mature conoid, tubulin is arranged into a novel polymer form that is quite different from typical microtubules.
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影响因子：
56.9
作者：
LEWIS, SA;WANG, DS;COWAN, NJ
通讯作者：
COWAN, NJ
DOI：
10.1083/jcb.72.3.642
发表时间：
1977-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Amos LA
通讯作者：
Amos LA
影响因子：
7.8
作者：
BURTON, PR;HIMES, RH
通讯作者：
HIMES, RH
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影响因子：
7.8
作者：
McIntosh, J R;Euteneuer, U
通讯作者：
Euteneuer, U
影响因子：
19
作者：
AMOS, LA
通讯作者：
AMOS, LA