Challenges of using protein antibiotics for pathogen control.
Challenges of using protein antibiotics for pathogen control.
复制标题
使用蛋白质抗生素控制病原体的挑战。
DOI：
10.1002/ps.6312
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发表时间：
2021
影响因子：
4.1
通讯作者：
Chai R
中科院分区：
文献类型：
--
作者：
Chai R
细菌性植物病原体对许多重要的经济作物构成重大威胁。目前的控制措施往往对环境造成损害，并可能通过抗生素耐药性的传播最终影响人类健康。抗菌蛋白如细菌素已被建议作为下一代疾病控制剂，因为它们能够特异性靶向感兴趣的病原体，对更广泛的微生物群落和环境的影响最小。然而，关于细菌素防治植物病原性细菌的功效和应用的知识仍然存在巨大差距。在这里，我们强调了社区必须解决的紧迫挑战，以确保最大限度地利用该领域的抗菌蛋白。© 2021 The Authors.Pest Management Sciencepublished by John Wiley & Sons Ltd代表化学工业协会。
Bacterial phytopathogens represent a significant threat to many economically important crops. Current control measures often inflict harm on the environment and may ultimately impact on human health through the spread of antibiotic resistance. Antimicrobial proteins such as bacteriocins have been suggested as the next generation of disease control agents since they are able to specifically target the pathogen of interest with minimal impact on the wider microbial community and environment. However, substantial gaps in knowledge with regards to the efficacy and application of bacteriocins to combat phytopathogenic bacteria remain. Here we highlight the immediate challenges the community must address to ensure maximum exploitation of antimicrobial proteins in the field. © 2021 The Authors.Pest Management Sciencepublished by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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DOI：
10.1073/pnas.1713741114
发表时间：
2017-11-07
影响因子：
11.1
作者：
White P;Joshi A;Rassam P;Housden NG;Kaminska R;Goult JD;Redfield C;McCaughey LC;Walker D;Mohammed S;Kleanthous C
通讯作者：
Kleanthous C
影响因子：
5.6
作者：
Stephan A;Hahn-Löbmann S;Rosche F;Buchholz M;Giritch A;Gleba Y
通讯作者：
Gleba Y
DOI：
10.1073/pnas.0602965103
发表时间：
2006-06-06
影响因子：
11.1
作者：
Kim, Jung-Gun;Park, Young Keun;Hwang, Ingyu
通讯作者：
Hwang, Ingyu
影响因子：
2.9
作者：
McNulty, Matthew J.;Gleba, Yuri;McDonald, Karen A.
通讯作者：
McDonald, Karen A.