Association between Domperidone Administered via Feeding Tube and Feeding Success in Critically Ill Patients with Enteral Feeding Intolerance.
Association between Domperidone Administered via Feeding Tube and Feeding Success in Critically Ill Patients with Enteral Feeding Intolerance.
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通过饲管给予多潘立酮与肠内喂养不耐受的危重患者喂养成功之间的关系
DOI：
10.3390/jpm11090846
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发表时间：
2021-08-27
影响因子：
--
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Cheng Y;Chen C;Yang H;Fu M;Zhong X;Wang B;Hu Z;He M;Zhang Z;Jin X;Kang Y;Wu Q
危重患者的一个营养挑战是肠内喂养不耐受（EFI），但目前的促动力学药物的疗效和安全性尚不确定。我们进行了一项纵向、单中心、回顾性研究，以评估成年EFI患者通过饲管给药多潘立酮与静脉注射（IV）甲氧氯普胺的有效性和安全性。主要终点是喂养成功，定义为每日蛋白质处方平均百分比>达到目标剂量80%的患者比例。次要终点是安全终点。在28,814例重症监护病房（ICU）入院患者中，纳入552例EFI患者，38例接受静脉注射甲氧氯普胺，514例接受管饲多潘立酮。管饲多潘立酮和静脉注射甲氧氯普胺的患者喂养成功率分别为42.02%和21.05%。经1:2匹配（静脉注射甲氧氯普胺与管饲多潘立酮）后，管饲多潘立酮患者喂养成功率为40.79%。配对后，两组患者在任何安全终点（死亡率、ICU和住院时间、器官支持治疗免费天数）和不良事件（EFI复发、电解质紊乱、腹部及其他症状）方面基本无差异（p < 0.05）。匹配队列的逻辑回归分析表明，通过喂食管给药的多潘立酮与喂养成功独立相关。我们发现管饲多潘立酮能有效提高EFI重症成人患者的肠内营养输送性能。
One nutritional challenge in critically ill patients is enteral feeding intolerance (EFI), but current prokinetic agents have uncertain efficacy and safety profiles. We conducted a longitudinal, single-center, retrospective study to evaluate the efficacy and safety of domperidone administered via the feeding tube versus intravenous (IV) metoclopramide among adult patients with EFI. The primary outcome was feeding success, defined as the proportion of patients with average percentage of daily protein prescription >80% of the target dose. The secondary outcomes were safety endpoints. Among 28,814 intensive care unit (ICU) admissions, 552 patients with EFI were included, 38 receiving IV metoclopramide and 514 receiving tube feeding domperidone. The proportion of feeding success in patients receiving tube feeding domperidone and IV metoclopramide was 42.02% and 21.05%, respectively. After 1:2 matching (IV metoclopramide to tube feeding domperidone), the proportion of feeding success was 40.79% in patients receiving tube feeding domperidone. Basically, after matching, there were no differences in any safety endpoints (mortality and length of stay during ICU and hospitalization, organ-support-treatment free days) or adverse events (recurrence of EFI, electrolyte disturbance, abdominal and other symptoms) between the two groups (p > 0.05). A logistic regression analysis in the matched cohort indicated that domperidone administered via the feeding tube was independently associated with feeding success. We found that tube feeding domperidone was efficient in increasing enteral nutrition delivery performance among critically ill adult patients with EFI.
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重症监护24×7：但是，为什么重症营养会中断呢？
DOI：
10.4103/0972-5229.128704
发表时间：
2014-03
期刊：
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
影响因子：
--
作者：
Ramakrishnan N;Daphnee DK;Ranganathan L;Bhuvaneshwari S
通讯作者：
Bhuvaneshwari S
DOI：
10.1007/s40800-018-0090-3
发表时间：
2018-08-07
期刊：
Drug safety - case reports
影响因子：
--
作者：
Sijtsma LC;Keijsers CJPW;Kerckhoffs APM;Agema WRP;Bootsma JEM
通讯作者：
Bootsma JEM
影响因子：
1.4
作者：
Baradari, Afshin Gholipour;Khajavi, Mohammad Reza;Sahebkar, Amirhossein
通讯作者：
Sahebkar, Amirhossein
影响因子：
1.6
作者：
Mancilla Asencio, C.;Galvez-Arevalo, L. R.;Madrid-Silva, A. M.
通讯作者：
Madrid-Silva, A. M.
影响因子：
3.4
作者：
Nicolo, Michele;Heyland, Daren K.;Compher, Charlene
通讯作者：
Compher, Charlene