Evaluation of a low-cost, portable imaging system for early detection of oral cancer.
Evaluation of a low-cost, portable imaging system for early detection of oral cancer.
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DOI：
10.1186/1758-3284-2-10
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发表时间：
2010-04-22
期刊：
影响因子：
--
通讯作者：
Chaturvedi P
中科院分区：
文献类型：
--
作者：
Rahman MS;Ingole N;Roblyer D;Stepanek V;Richards-Kortum R;Gillenwater A;Shastri S;Chaturvedi P
全球有一个重要的需求来改进口腔癌的早期检测。最近的报告表明，光学成像技术可以帮助识别口腔中的肿瘤病变；然而，在资源有限的情况下评估光学成像模式的使用的数据很少，因为口腔癌对患者的影响不成比例。在这篇文章中，我们评估了一个简单，低成本的光学成像系统，它是为在资源有限的情况下早期检测口腔癌而设计的。我们报告了在印度孟买的塔塔纪念医院(TMH)进行的一项临床研究的结果，该系统作为一种工具来改进口腔癌及其前驱疾病的检测。对76例患者的261个口腔部位和33名正常志愿者的90个部位进行了白光反射成像和455 nm激发的荧光成像。定量图像特征被用来开发识别肿瘤组织的分类算法，以专家观察员的临床诊断为金标准。使用红色和绿色的自发荧光比率，该算法识别临床判断为癌症或临床可疑肿瘤的组织，敏感度为90%，特异度为87%。结果表明，这一简单、客观、低成本的系统的性能具有改善口腔筛查工作的潜力，特别是在低资源环境下。
There is an important global need to improve early detection of oral cancer. Recent reports suggest that optical imaging technologies can aid in the identification of neoplastic lesions in the oral cavity; however, there is little data evaluating the use of optical imaging modalities in resource limited settings where oral cancer impacts patients disproportionately. In this article, we evaluate a simple, low-cost optical imaging system that is designed for early detection of oral cancer in resource limited settings. We report results of a clinical study conducted at Tata Memorial Hospital (TMH) in Mumbai, India using this system as a tool to improve detection of oral cancer and its precursors. Reflectance images with white light illumination and fluorescence images with 455 nm excitation were obtained from 261 sites in the oral cavity from 76 patients and 90 sites in the oral cavity from 33 normal volunteers. Quantitative image features were used to develop classification algorithms to identify neoplastic tissue, using clinical diagnosis of expert observers as the gold standard. Using the ratio of red to green autofluorescence, the algorithm identified tissues judged clinically to be cancer or clinically suspicious for neoplasia with a sensitivity of 90% and a specificity of 87%. Results suggest that the performance of this simple, objective low-cost system has potential to improve oral screening efforts, especially in low-resource settings.
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DOI：
10.1002/hed.10381
发表时间：
2004-03-01
影响因子：
2.9
作者：
Svistun, E;Alizadeh-Naderi, R;Richards-Kortum, R
通讯作者：
Richards-Kortum, R
影响因子：
168.9
作者：
Sankaranarayanan, R;Ramadas, K;Rajan, B
通讯作者：
Rajan, B
DOI：
10.1002/hed.20468
发表时间：
2007-01-01
影响因子：
2.9
作者：
Poh, Catherine F.;Ng, Samson P.;Rosin, Miriam P.
通讯作者：
Rosin, Miriam P.
DOI：
10.1158/1940-6207.capr-08-0229
发表时间：
2009-05
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Roblyer D;Kurachi C;Stepanek V;Williams MD;El-Naggar AK;Lee JJ;Gillenwater AM;Richards-Kortum R
通讯作者：
Richards-Kortum R
DOI：
10.1046/j.1365-263x.2002.00373.x
发表时间：
2002-07-01
影响因子：
3.8
作者：
Yusuf, H;Yong, S L
通讯作者：
Yong, S L