Weekly prenatal PM2.5 and NO2 exposures in preterm, early term, and full term infants: Decrements in birth weight and critical windows of susceptibility.
Weekly prenatal PM2.5 and NO2 exposures in preterm, early term, and full term infants: Decrements in birth weight and critical windows of susceptibility.
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早产儿、早产儿和足月儿每周产前 PM2.5 和 NO2 暴露：出生体重和关键易感性窗口的减少。
DOI：
10.1016/j.envres.2023.117509
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发表时间：
2024
影响因子：
8.3
通讯作者：
Miranda,MarieLynn
中科院分区：
文献类型：
--
作者：
Bravo,MercedesA;Zephyr,Dominique;Fiffer,MelissaR;Miranda,MarieLynn
背景以前的研究已经观察到出生体重和产前空气污染暴露之间的联系，但在敏感性的关键窗口的时间上没有达成共识。早产和足月分娩与整个妊娠期每周暴露于PM2.5和NO2相关。方法我们包括密歇根州下半岛的所有单胎活产（美国）在2007年至2012年期间发生在胎龄32周或之后（n = 497，897）。每周环境PM2.5和NO2浓度估计在产妇住所使用1公里网格数据集成为基础的模型。我们利用分布滞后非线性模型来估计早产儿从末次月经期（第0周）至妊娠31周的每周暴露量相关的出生体重差异;早产儿至妊娠36周的每周暴露量相关的出生体重差异;在单污染物模型中，PM2.5暴露量增加5 μg/m3，早产儿出生体重下降（−37.1 g [95%置信区间[CI]：60.8 g，−13.5 g]）;早产（−13.5 g [95% CI：26.2 g，−0.67 g]）;足月分娩（−8.23 g [95% CI：15.8 g，−0.68 g]）]。在单一污染物模型中，NO2暴露增加10 ppb仅与足月新生儿出生体重减少−11.7 g（95% CI：14.46 g，−8.92 g）相关。在PM2.5和NO2共同调整的模型中，PM2.5暴露与早产儿的出生体重降低相关（−36.9 g [95% CI：61.9 g，−11.8 g]），NO2暴露与足月出生体重降低相关（−11.8 g [95% CI：14.7 g，−8.94 g]）。出生体重的最大降幅与PM2.5暴露有关，大约在怀孕10至26周之间;对于NO2暴露，足月新生儿出生体重的最大下降与6- 18周之间的暴露有关。结论我们观察到PM2.5暴露与早产儿出生体重之间最大和最持久的不利关系，足月儿NO2暴露量与出生体重的关系。怀孕前半期的暴露对出生体重的影响更大。
BackgroundPrevious studies have observed associations between birth weight and prenatal air pollution exposure, but there is not consensus on timing of critical windows of susceptibility.ObjectiveWe estimated the difference in birth weight among preterm, early term and full term births associated with weekly exposure to PM2.5and NO2throughout gestation.MethodsWe included all singleton live births in the Lower Peninsula of Michigan (United States) between 2007 and 2012 occurring at or after 32 weeks gestational age (n = 497,897). Weekly ambient PM2.5and NO2concentrations were estimated at maternal residences using 1-km gridded data from ensemble-based models. We utilized a distributed lag nonlinear model to estimate the difference in birth weight associated with weekly exposures from the last menstrual period (week 0) through 31 weeks gestation for preterm births; through 36 weeks gestation for early term births; and through 38 weeks gestation for full term births.ResultsIn single-pollutant models, a 5 μg/m3increase in PM2.5exposure was associated with a reduction in birth weight among preterm births (−37.1 g [95% confidence interval [CI]: 60.8 g, −13.5 g]); early term births (−13.5 g [95% CI: 26.2 g, −0.67 g]); and full term births (−8.23 g [95% CI: 15.8 g, −0.68 g])]. In single-pollutant models, a 10 ppb increase in NO2exposure was associated with a −11.7 g (95% CI: 14.46 g, −8.92 g) decrement in birth weight among full term births only. In models co-adjusted for PM2.5and NO2, PM2.5exposure was associated with reduced birth weight among preterm births (−36.9 g [95% CI: 61.9 g, −11.8 g]) and NO2exposure was associated with reduced birth weight among full term births (−11.8 g [95% CI: 14.7 g, −8.94 g]). The largest decrements in birth weight were associated with PM2.5exposure between approximately 10 and 26 weeks of pregnancy; for NO2exposure, the largest decrements in birth weight in full term births were associated with exposure between weeks 6–18.ConclusionWe observed the largest and most persistent adverse associations between PM2.5exposure and birth weight in preterm infants, and between NO2exposure and birth weight in full term infants. Exposure during the first half of pregnancy had a greater impact on birthweight.
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影响因子：
5.6
作者：
Schieve LA;Tian LH;Rankin K;Kogan MD;Yeargin-Allsopp M;Visser S;Rosenberg D
通讯作者：
Rosenberg D
DOI：
10.1097/ede.0000000000001348
发表时间：
2021-07-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Son JY;Sabath MB;Lane KJ;Miranda ML;Dominici F;Di Q;Schwartz J;Bell ML
通讯作者：
Bell ML
DOI：
--
发表时间：
2017
期刊：
--
影响因子：
--
作者：
A. Wilson;Y. Chiu;H. Hsu;R. Wright;Rosalind J Wright;B. Coull
通讯作者：
A. Wilson;Y. Chiu;H. Hsu;R. Wright;Rosalind J Wright;B. Coull
影响因子：
3.6
作者：
Mattison DR
通讯作者：
Mattison DR
影响因子：
2.1
作者：
Bobb, Jennifer F.;Valeri, Linda;Coull, Brent A.
通讯作者：
Coull, Brent A.