Advances in the genetics of endometriosis.
Advances in the genetics of endometriosis.
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DOI：
10.1186/gm196
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发表时间：
2010-10-14
期刊：
影响因子：
12.3
通讯作者：
Wieser F
中科院分区：
文献类型：
--
作者：
Dun EC;Taylor RN;Wieser F
Endometriosis is a gynecological disease characterized by implantation of endometrial tissue outside of the uterus. Early familial aggregation and twin studies noted a higher risk of endometriosis among relatives. Studies on the roles of the environment, genetics and aberrant regulation in the endometrium and endometriotic lesions of women with endometriosis suggest that endometriosis arises from the interplay between genetic variants and environmental factors. Elucidating the hereditary component has proven difficult because multiple genes seem to produce a susceptibility to developing endometriosis. Molecular techniques, including linkage and genome-wide analysis, have identified candidate genes located near known loci related to development and regulation of the female reproductive tract. As new candidate genes are discovered and hereditary pathways identified using technologies such as genome-wide analysis, the possibility of prevention and treatment becomes more tangible for millions of women affected by endometriosis. Here, we discuss the advances of genetic research in endometriosis and describe technologies that have contributed to the current understanding of the genetic variability in endometriosis, variability that includes regulatory polymorphisms in key genes.
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DOI：
10.1161/circgenetics.108.793158
发表时间：
2008-12
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Horne BD;Carlquist JF;Muhlestein JB;Bair TL;Anderson JL
通讯作者：
Anderson JL
影响因子：
2.7
作者：
Bulun SE;Cheng YH;Pavone ME;Xue Q;Attar E;Trukhacheva E;Tokunaga H;Utsunomiya H;Yin P;Luo X;Lin Z;Imir G;Thung S;Su EJ;Kim JJ
通讯作者：
Kim JJ
DOI：
10.1056/nejmra0808700
发表时间：
2009-04-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hardy J;Singleton A
通讯作者：
Singleton A
影响因子：
2.7
作者：
Hsieh, YY;Chang, CC;Tsai, CH
通讯作者：
Tsai, CH
影响因子：
6.1
作者：
Kitawaki, J;Obayashi, H;Honjo, H
通讯作者：
Honjo, H