A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior.
A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior.
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DOI：
10.1186/1752-0509-4-81
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发表时间：
2010-06-07
影响因子：
--
通讯作者：
Breitling R
中科院分区：
文献类型：
--
作者：
Zhang M;Schafer WR;Breitling R
产卵行为的线虫C。秀丽隐杆线虫表现出一种独特的集群时间模式：产卵事件主要发生在爆发期或活跃期，由保留卵的非活跃期隔开。活跃期的开始可以被建模为具有大约20分钟的时间常数的泊松过程，而活跃期内的产卵事件以大约20秒的较快时间常数发生。在这里，我们提出了一个细胞模型的时间模式的产卵可能会产生，遗传和细胞生物学实验和统计分析的基础上。我们认为HSN神经元是驱动产卵事件的执行神经元。我们建议，VC神经元作为“单蛋计数器”，抑制HSN活动在短期内响应个别产卵事件。我们进一步提出，uv1神经内分泌细胞是“簇计数器”，它抑制HSN活动的时间较长，并负责非活动期的时间常数。它们一起形成一个集成电路，驱动集群产卵模式。从这个模型得到的详细预测现在可以通过简单的验证实验进行测试。
Egg-laying behavior in the nematode C. elegans displays a distinct clustered temporal pattern: egg-laying events occur primarily in bursts or active phases, separated by inactive phases during which eggs are retained. The onset of the active phase can be modeled as a Poisson process with a time constant of approximately 20 minutes, while egg-laying events within an active phase occur with a faster time constant of approximately 20 seconds. Here we propose a cellular model for how the temporal pattern of egg-laying might be generated, based on genetic and cell-biological experiments and statistical analyses. We suggest that the HSN neuron is the executive neuron driving egg-laying events. We propose that the VC neurons act as "single egg counters" that inhibit HSN activity for short periods in response to individual egg-laying events. We further propose that the uv1 neuroendocrine cells are "cluster counters", which inhibit HSN activity for longer periods and are responsible for the time constant of the inactive phase. Together they form an integrated circuit that drives the clustered egg-laying pattern. The detailed predictions derived from this model can now be tested by straightforward validation experiments.
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影响因子：
16.2
作者：
Suzuki, H;Kerr, R;Schafer, WR
通讯作者：
Schafer, WR
影响因子：
2.5
作者：
Norris, Brian J.;Weaver, Adam L.;Calabrese, Ronald L.
通讯作者：
Calabrese, Ronald L.
影响因子：
16.2
作者：
Alkema, MJ;Hunter-Ensor, M;Horvitz, HR
通讯作者：
Horvitz, HR
影响因子：
3.3
作者：
Jose, Antony M.;Bany, I. Amy;Koelle, Michael R.
通讯作者：
Koelle, Michael R.
一个自我调节的馈电回路，控制了秀丽隐杆线虫卵形的行为。
影响因子：
9.2
作者：
Zhang, Mi;Chung, Samuel H.;Fang-Yen, Chris;Craig, Caroline;Kerr, Rex A.;Suzuki, Hiroshi;Samuel, Aravinthan D. T.;Mazur, Eric;Schafer, William R.
通讯作者：
Schafer, William R.