Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
Modulating intrinsic connectivity: adjacent subregions within supplementary motor cortex, dorsolateral prefrontal cortex, and parietal cortex connect to separate functional networks during task and also connect during rest.
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DOI：
10.1371/journal.pone.0090672
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Constable RT
中科院分区：
文献类型：
--
作者：
Roth JK;Johnson MK;Tokoglu F;Murphy I;Constable RT
辅助运动区（SMA）、额下交界区（IFJ）、额上交界区（SFJ）和顶叶皮层在许多认知任务中都很活跃。在之前的一项研究中，我们发现这些主要区域的子区域在工作记忆任务期间执行功能的组成过程中表现出不同的活跃程度。在本研究中，这些子区域中的每一个都被用作工作记忆和静息状态数据的全脑功能连接分析的种子。这些区域显示出与不同网络的功能连接，从而支持将这些主要区域分割成功能子区域。许多在工作记忆残留数据（从数据中回归任务事件）期间显示出显着连接的区域在休息期间也显着连接，这表明这些与皮层主要区域内的子区域的网络连接是内在的。对于其中一些连接，任务要求调节这些内在网络中的活动。大约一半在任务期间重要的连接在休息期间也很重要，这表明一些连接是内在的，而另一些连接只是为了任务而招募的。此外，与传统“任务正向”和“任务负向”（又称“默认模式”）区域的网络连接根据任务需求从正连接转变为负连接。这些发现表明，这些任务识别的子区域是不同网络的一部分，并且这些网络与休息时一样具有不同的任务连接模式，与任务积极区域和任务消极区域都有联系。这些结果对于理解共同活跃区域划分为更具体的功能网络具有重要意义。
Supplementary motor area (SMA), the inferior frontal junction (IFJ), superior frontal junction (SFJ) and parietal cortex are active in many cognitive tasks. In a previous study, we found that subregions of each of these major areas were differentially active in component processes of executive function during working memory tasks. In the present study, each of these subregions was used as a seed in a whole brain functional connectivity analysis of working memory and resting state data. These regions show functional connectivity to different networks, thus supporting the parcellation of these major regions into functional subregions. Many regions showing significant connectivity during the working memory residual data (with task events regressed from the data) were also significantly connected during rest suggesting that these network connections to subregions within major regions of cortex are intrinsic. For some of these connections, task demands modulate activity in these intrinsic networks. Approximately half of the connections significant during task were significant during rest, indicating that some of the connections are intrinsic while others are recruited only in the service of the task. Furthermore, the network connections to traditional ‘task positive’ and ‘task negative’ (a.k.a ‘default mode’) regions shift from positive connectivity to negative connectivity depending on task demands. These findings demonstrate that such task-identified subregions are part of distinct networks, and that these networks have different patterns of connectivity for task as they do during rest, engaging connections both to task positive and task negative regions. These results have implications for understanding the parcellation of commonly active regions into more specific functional networks.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
13.9
作者：
Bisley JW;Goldberg ME
通讯作者：
Goldberg ME
影响因子：
4.8
作者：
Owen, AM;McMillan, KM;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
2.5
作者：
Fukunaga, Masaki;Horovitz, Silvina G.;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC