KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism.
KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism.
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DOI：
10.3390/ijms22105070
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发表时间：
2021-05-11
影响因子：
5.6
通讯作者：
Yoo BC
中科院分区：
文献类型：
--
作者：
Muyinda IJ;Park JG;Jang EJ;Yoo BC
柯尔斯滕鼠肉瘤病毒癌基因同源基因(KRAS)驱动的胰腺癌是非常致命的，无论治疗进展如何，五年存活率均为9%。由于胰腺肿瘤的特殊性，包括化疗、放射治疗和免疫治疗在内的不同治疗方法仅显示出微乎其微的疗效。尽管只有20%的早期患者接受手术，但早期手术仍然是唯一的治愈选择。针对主要致癌驱动因素KRAS的临床试验在很大程度上没有成功。最近，在胰腺癌患者和致癌的KRAS小鼠模型中发现了全球代谢重编程。新近重新编程的代谢途径和肿瘤代谢物会影响肿瘤的形成环境。胰腺癌细胞代谢重编程调控方法的发展可能构成胰腺癌细胞治疗的新途径。在这篇综述中，我们描述了提供乙酰辅酶A和NADPH的主要代谢途径，它们是维持胰腺癌细胞脂质合成和细胞增殖所必需的。
Kirsten rat sarcoma viral oncogene homolog (KRAS)-driven pancreatic cancer is very lethal, with a five-year survival rate of <9%, irrespective of therapeutic advances. Different treatment modalities including chemotherapy, radiotherapy, and immunotherapy demonstrated only marginal efficacies because of pancreatic tumor specificities. Surgery at the early stage of the disease remains the only curative option, although only in 20% of patients with early stage disease. Clinical trials targeting the main oncogenic driver, KRAS, have largely been unsuccessful. Recently, global metabolic reprogramming has been identified in patients with pancreatic cancer and oncogenic KRAS mouse models. The newly reprogrammed metabolic pathways and oncometabolites affect the tumorigenic environment. The development of methods modulating metabolic reprogramming in pancreatic cancer cells might constitute a new approach to its therapy. In this review, we describe the major metabolic pathways providing acetyl-CoA and NADPH essential to sustain lipid synthesis and cell proliferation in pancreatic cancer cells.
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影响因子：
4.2
作者：
Baines AT;Xu D;Der CJ
通讯作者：
Der CJ
影响因子：
4.8
作者：
Conradt, Laura;Godl, Klaus;Schneider, Guenter
通讯作者：
Schneider, Guenter
影响因子：
21.1
作者：
Anderson NM;Mucka P;Kern JG;Feng H
通讯作者：
Feng H
顺铂耐药细胞中谷氨酰胺消耗增加对细胞生长产生负面影响
影响因子：
4.6
作者：
Duan G;Shi M;Xie L;Xu M;Wang Y;Yan H;Zhuge Y;Zou X
通讯作者：
Zou X
影响因子：
16
作者：
DeNicola GM;Cantley LC
通讯作者：
Cantley LC