Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011.
Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011.
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DOI：
10.1371/journal.pone.0131646
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Bausch DG
中科院分区：
文献类型：
--
作者：
Ballard SB;Reaves EJ;Luna CG;Silva ME;Rocha C;Heitzinger K;Saito M;Apaza S;Espetia S;Blazes DL;Tilley DH;Guzmán Aguilar RC;Gilman RH;Bausch DG
成功的诺沃克病毒疫苗接种战略将需要了解疾病的负担和人口中的相关基因类型。然而，对生活在低收入和中等收入国家(LMIC)的成年人进行的队列研究提供的数据很少。我们在秘鲁军队队列中进行了一项嵌套病例对照研究，以确定2004年至2011年诺沃克病毒感染的负担、主要基因类型和相关症状。随机选择病例和对照粪便进行诺沃克病毒、细菌和寄生虫检测。使用多元Logistic回归估计诺如病毒感染和腹泻之间的关联的优势比，并计算合并感染调整后的归因分数。在3818名队列研究参与者中，624人出现腹泻。总发病率和诺如病毒相关性腹泻发病率分别为每100人年42.3和6.0。最常见的诺如病毒基因群为GII(72.5%，29/40)，与腹泻有关(AOR3.4，95%CI：1.3~8.7，P=0.012)。合并感染调整后的GII归因分数为6.4%。诺沃克病毒是成人腹泻的常见原因，在LMIC环境中纵向紧随其后。疫苗战略应考虑以地方病流行环境中的成年人和可能成为社区传播源的特殊人群为目标。
Successful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries (LMIC). We conducted a nested case-control study within a Peruvian military cohort to characterize the burden of norovirus infection, predominant genotypes, and associated symptoms from 2004 through 2011. Randomly selected case and control stools were tested for norovirus, bacteria, and parasites. The odds ratio of the association between norovirus infection and diarrhea was estimated using multiple logistic regression and co-infection adjusted attributable fractions were calculated. Of the 3,818 cohort study participants, 624 developed diarrhea. Overall and norovirus-associated diarrhea incidence rates were 42.3 and 6.0 per 100 person-years, respectively. The most prevalent norovirus genogroup was GII (72.5%, 29/40), which was associated with diarrhea (AOR 3.4, 95% CI: 1.3–8.7, P = 0.012). The co-infection adjusted GII attributable fraction was 6.4%. Norovirus was a frequent cause of diarrhea in an adult population followed longitudinally in an LMIC setting. Vaccine strategies should consider targeting adults in endemic settings and special populations that could serve as community transmission sources.
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DOI：
10.1056/nejmoa1101245
发表时间：
2011-12-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Atmar RL;Bernstein DI;Harro CD;Al-Ibrahim MS;Chen WH;Ferreira J;Estes MK;Graham DY;Opekun AR;Richardson C;Mendelman PM
通讯作者：
Mendelman PM
影响因子：
11.8
作者：
Lee N;Chan MC;Wong B;Choi KW;Sin W;Lui G;Chan PK;Lai RW;Cockram CS;Sung JJ;Leung WK
通讯作者：
Leung WK
影响因子：
3.2
作者：
Blanco Fernandez, Maria D.;Torres, Carolina;Mbayed, Viviana A.
通讯作者：
Mbayed, Viviana A.
影响因子：
12.7
作者：
Ferreira, M. S. R.;Victoria, M.;Miagostovich, M. P.
通讯作者：
Miagostovich, M. P.
影响因子：
5
作者：
Lopman, Ben;Simmons, Kirsten;Parashar, Umesh
通讯作者：
Parashar, Umesh