Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring.
Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring.
复制标题
发育暴露于吲哚-3-甲醇或2,3,7,8-四氯二苯并-对二恶英对雄性大鼠后代生殖潜力的影响。
DOI：
10.1006/taap.1996.0261
复制
发表时间：
1996
影响因子：
3.8
通讯作者：
Safe,S
中科院分区：
文献类型：
--
作者：
Wilker,C;Johnson,L;Safe,S
在妊娠第15天单次口服2，3，7，8-四氯二苯并-对-二恶英（TCDD）对妊娠雌性Sprague-Dawley大鼠进行处理（0.5、1.0或2.0μg/kg）或吲哚-3-甲醇（I3 C，1.0或100 mg/kg），一种在十字花科蔬菜中发现的芳烃（Ah）受体激动剂，导致雄性后代的生殖异常（每个处理组中3 - 5窝）。两种化合物均改变了肛门生殖器距离和顶臀长度;然而，效应的时间（第1天或第5天）是可变的，并且反应不一定具有剂量依赖性。在62天大的后代中，一个或多个剂量的TCDD降低了精囊（24 - 26%）、前列腺（32 - 44%）、睾丸实质（14%）和附睾重量（19%）。相比之下，I3 C在一个或多个剂量降低每日精子产量/克睾丸实质（13至20%）和每日精子产量/睾丸（22%）。在围产期暴露于TCDD的大鼠中，附睾中的精子总数显著减少（30 - 33%），这是由于附睾尾部的精子数量减少（49 - 51%）。围产期暴露于I3 C没有影响任何这些参数。在任何剂量（0.5 - 2.0μg/kg）下，TCDD均不影响精子通过整个附睾的附睾通过时间。然而，在两个最高剂量（1.0和2.0μg/kg）下，TCDD使精子通过附睾尾部的附睾通过率分别增加了33%和37%。相比之下，I3 C（1 mg/kg）显著增加了31%的总附睾通过时间，这主要是由于精子通过附睾头部和体部的通过率降低（39%）。总之，妊娠大鼠围产期暴露于I3 C，一种Ah受体激动剂类似于TCDD，导致雄性大鼠后代的生殖异常;然而，I3 C和TCDD引起共同和不同的反应。
Treatment of pregnant female Sprague-Dawley rats on Gestational Day 15 with a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (0.5, 1.0, or 2.0μg/kg) or indole-3-carbinol (I3C, 1.0 or 100 mg/kg), an aryl hydrocarbon (Ah) receptor agonist which is found in cruciferous vegetables, resulted in reproductive abnormalities in the male offspring (three to five litters in each treatment group). Anogenital distance and crown to rump length were altered by both compounds; however, the timing of the effects (Day 1 or 5) was variable and the responses were not necessarily dose-dependent. In 62-day-old offspring, seminal vesicle (24 to 26%), prostate (32 to 44%), testicular parenchymal (14%), and epididymal weight (19%) were decreased by one or more doses of TCDD. In contrast, I3C at one or more doses decreased daily sperm production/g testicular parenchyma (13 to 20%) and daily sperm production/testis (22%). Total number of sperm in the epididymis was significantly decreased (30 to 33%) in rats perinatally exposed to TCDD and this was due to a decreased (49 to 51%) number of sperm in the tail of the epididymis. Perinatal exposure to I3C did not affect any of these parameters. TCDD did not affect epididymal transit time of sperm through the complete epididymis at any of the doses (0.5 to 2.0μg/kg). However, at the two highest doses (1.0 and 2.0μg/kg), TCDD increased epididymal transit rate of sperm through the tail of the epididymis by 33 and 37%, respectively. In contrast, primarily due to decreased transit rate (39%) of sperm through the head plus body of the epididymis, I3C (1 mg/kg) significantly increased total epididymal transit time by 31%. In conclusion, perinatal exposure of pregnant rats to I3C, an Ah receptor agonist similar to TCDD, causes reproductive abnormalities in male rat offspring; however, I3C and TCDD elicited both common and different responses.
登录
查看更多内容
影响因子：
3.8
作者：
GRAY, LE;KELCE, WR;BIRNBAUM, LS
通讯作者：
BIRNBAUM, LS
影响因子：
7.8
作者：
E. Weibel;D. Paumgartner
通讯作者：
D. Paumgartner
化学致癌物和饮食相关癌症中的营养过剩。
影响因子：
4.7
作者：
Werner Lutz
通讯作者：
Werner Lutz
影响因子：
64.8
作者：
MEISTRICH, ML;HUGHES, TJ;BRUCE, WR
通讯作者：
BRUCE, WR
影响因子：
5.8
作者：
Chen, I;Safe, S;Bjeldanes, L
通讯作者：
Bjeldanes, L