Domestication and the mitochondrial genome: comparing patterns and rates of molecular evolution in domesticated mammals and birds and their wild relatives.
Domestication and the mitochondrial genome: comparing patterns and rates of molecular evolution in domesticated mammals and birds and their wild relatives.
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DOI：
10.1093/gbe/evu005
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发表时间：
2014-01
影响因子：
3.3
通讯作者：
Bromham L
中科院分区：
文献类型：
--
作者：
Moray C;Lanfear R;Bromham L
对驯化动物的研究表明，驯化可能对分子进化模式产生重大影响。特别是，从国内的狗和牦牛的线粒体基因组序列的分析已经产生了较高的比例的非同义同义的替代驯化的血统比在他们的野生亲戚。这些结果很重要，因为它们意味着在短时间内选择或种群规模的变化可能会导致线粒体分子进化模式的显着变化。在这项研究中，我们的目的是测试对线粒体基因组进化的影响是否是驯化的一般特征，或者它是否是特定的例子。我们测试驯化的哺乳动物和鸟类是否有一贯不同的模式的分子进化比他们的野生亲属的16个遗传学上独立的比较线粒体基因组序列。我们发现驯化和野生谱系之间的分支长度或dN/dS没有一致的差异。我们也没有发现任何证据表明，我们未能检测到一致的模式是由于所涉及的时间尺度短或驯化谱系与其野生亲属之间的遗传距离较低。然而，删除比较野生亲属也可能经历了一个瓶颈，揭示了一个模式与减少有效的人口规模在驯化血统。我们的研究结果表明，虽然一些驯化谱系可能已经经历了选择制度或有效的人口规模，可能会影响线粒体进化的变化，这是不可能概括这些模式在所有驯化的哺乳动物和鸟类。
Studies of domesticated animals have led to the suggestion that domestication could have significant effects on patterns of molecular evolution. In particular, analyses of mitochondrial genome sequences from domestic dogs and yaks have yielded higher ratios of non-synonymous to synonymous substitutions in the domesticated lineages than in their wild relatives. These results are important because they imply that changes to selection or population size operating over a short timescale can cause significant changes to the patterns of mitochondrial molecular evolution. In this study, our aim is to test whether the impact on mitochondrial genome evolution is a general feature of domestication or whether it is specific to particular examples. We test whether domesticated mammals and birds have consistently different patterns of molecular evolution than their wild relatives for 16 phylogenetically independent comparisons of mitochondrial genome sequences. We find no consistent difference in branch lengths or dN/dS between domesticated and wild lineages. We also find no evidence that our failure to detect a consistent pattern is due to the short timescales involved or low genetic distance between domesticated lineages and their wild relatives. However, removing comparisons where the wild relative may also have undergone a bottleneck does reveal a pattern consistent with reduced effective population size in domesticated lineages. Our results suggest that, although some domesticated lineages may have undergone changes to selective regime or effective population size that could have affected mitochondrial evolution, it is not possible to generalize these patterns over all domesticated mammals and birds.
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DOI：
10.1073/pnas.0409159102
发表时间：
2005-01-25
影响因子：
11.1
作者：
Gu, ZL;David, L;Steinmetz, LM
通讯作者：
Steinmetz, LM
影响因子：
3.3
作者：
Hugall, Andrew F.;Lee, Michael S. Y.
通讯作者：
Lee, Michael S. Y.
影响因子：
2.2
作者：
BLUMLER, MA;BYRNE, R;RILEY, TJ
通讯作者：
RILEY, TJ
影响因子：
4.5
作者：
Fang M;Larson G;Ribeiro HS;Li N;Andersson L
通讯作者：
Andersson L
DOI：
10.1073/pnas.0401720101
发表时间：
2004-07-20
影响因子：
11.1
作者：
Innan, H;Kim, Y
通讯作者：
Kim, Y