The role of sphingosine-1-phosphate in autophagy and related disorders.
The role of sphingosine-1-phosphate in autophagy and related disorders.
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DOI：
10.1038/s41420-023-01681-x
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发表时间：
2023-10-18
影响因子：
7
通讯作者：
Yu, Qin
中科院分区：
文献类型：
--
作者：
Xiao, Siqi;Peng, Kaixin;Li, Congxin;Long, Yuanyuan;Yu, Qin
S1 P，也称为鞘氨醇-1-磷酸，是一种具有生物活性的脂质分子，参与许多细胞过程，如细胞生长、运动、程序性细胞死亡、自降解、细胞特化、衰老和免疫系统反应。自噬是一种精心控制的机制，其中细胞重新利用其元素来维持细胞平衡。自噬过程分为五个阶段：起始、成核、延伸和成熟、融合和降解。新的研究深入了解了S1 P和自噬之间的复杂联系，揭示了它们在正常和异常情况下的相互作用。获得关于S1 P信号对自噬的调节机制的知识可以提供对其在健康和疾病中的功能的有价值的理解，可能导致各种疾病的创新治疗概念。因此，本文分析了哺乳动物自噬的基本阶段，特别强调了最近的研究探索每个阶段的控制S1 P。此外，它揭示了S1 P诱导的自噬在各种疾病中的作用。
S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed cell death, self-degradation, cell specialization, aging, and immune system reactions. Autophagy is a meticulously controlled mechanism in which cells repurpose their elements to maintain cellular balance. There are five stages in autophagy: initiation, nucleation, elongation and maturation, fusion, and degradation. New research has provided insight into the complex connection between S1P and autophagy, uncovering their interaction in both normal and abnormal circumstances. Gaining knowledge about the regulatory mechanism of S1P signaling on autophagy can offer a valuable understanding of its function in well-being and illness, potentially leading to innovative therapeutic concepts for diverse ailments. Hence, this review analyzes the essential stages in mammalian autophagy, with a specific emphasis on recent research exploring the control of each stage by S1P. Additionally, it sheds light on the roles of S1P-induced autophagy in various disorders.
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影响因子：
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作者：
Evangelisti C;Evangelisti C;Teti G;Chiarini F;Falconi M;Melchionda F;Pession A;Bertaina A;Locatelli F;McCubrey JA;Beak DJ;Bittman R;Pyne S;Pyne NJ;Martelli AM
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影响因子：
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Bouquerel P;Gstalder C;Müller D;Laurent J;Brizuela L;Sabbadini RA;Malavaud B;Pyronnet S;Martineau Y;Ader I;Cuvillier O
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DOI：
10.11909/j.issn.1671-5411.2018.05.003
发表时间：
2018-05
期刊：
Journal of geriatric cardiology : JGC
影响因子：
--
作者：
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通讯作者：
Liu HB