Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression
Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression
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与慢性心力衰竭相关的炎症会导致抑郁症的易感性增加
DOI：
10.1111/febs.14839
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发表时间：
2019-07
期刊：
影响因子：
5.4
通讯作者：
Huang Fang
中科院分区：
文献类型：
--
作者：
Su Jing;Wang Jinghui;Ma Yuanyuan;Li Qing;Yang Yufang;Huang Li;Wang Haoyue;Li Heng;Wang Zishan;Tong Jiabin;Huang Dongping;Bai Xiaochen;Yu Mei;Bu Liping;Fei Jian;Huang Fang
流行病学和临床病理学研究表明，患有神经精神障碍（如抑郁症）的患者发生慢性心力衰竭（CHF）的风险较高。然而，尚不清楚慢性心力衰竭是否会导致抑郁症，以及……（原文最后“und”不完整）
Epidemiological and clinicopathological studies indicate that there is a high risk for chronic heart failure (CHF) in patients suffering from neuropsychiatric disorders, such as depression. However, it is unclear whether CHF causes depression, and the underlying mechanisms of this association remain largely unknown. In this study, mice with myocardial infarction and CHF were used to investigate behavioral alterations as well as changes in the brain‐heart axis. During the first 6 months, abnormalities in neuropsychiatric behaviors were detected in mice with CHF. Using the sucrose preference test, a 9 months course of CHF resulted in two subgroups: mice with a significant decrease in sucrose preference, defined herein as “susceptible” (Sus), and mice with a normal sucrose preference, defined herein as “resilient.” Compared to the resilient and sham‐operated animals, the Sus mice displayed imbalances in glutamate transmission and hypothalamic–pituitary–adrenal axis activation, abnormal synaptic plasticity, and increased inflammatory responses. Furthermore, abnormal kynurenine metabolism was detected in Sus mice. Our results suggest that long‐term CHF increases inflammatory responses in the central nervous system and leads to depression in Sus mice.
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影响因子：
10.6
作者：
Miller, Andrew H.;Maletic, Vladimir;Raison, Charles L.
通讯作者：
Raison, Charles L.
朝着抑郁症的谷氨酸假说：情绪障碍神经心理药理的新兴前沿。
影响因子：
4.7
作者：
Sanacora, Gerard;Treccani, Giulia;Popoli, Maurizio
通讯作者：
Popoli, Maurizio
影响因子：
3.4
作者：
Adams, Julie;Kuchibhatla, Maragatha;Christopher, Eric J.;Alexander, Jude D.;Clary, Greg L.;Cuffe, Michael S.;Califf, Robert M.;Krishnan, Ranga R.;O'Connor, Christopher M.;Jiang, Wei
通讯作者：
Jiang, Wei
影响因子：
6.7
作者：
Raison, Charles L.;Miller, Andrew H.
通讯作者：
Miller, Andrew H.
影响因子：
3.3
作者：
Felger JC;Lotrich FE
通讯作者：
Lotrich FE