Association between the epidermal growth factor +61 G/A polymorphism and glioma risk: a meta-analysis.
Association between the epidermal growth factor +61 G/A polymorphism and glioma risk: a meta-analysis.
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DOI：
10.1371/journal.pone.0095139
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhao S
中科院分区：
文献类型：
--
作者：
Chen X;Yang G;Zhang D;Zhang W;Zou H;Zhao H;Zhang X;Zhao S
在原发的恶性脑肿瘤中，神经胶质瘤几乎占80%。由于表皮生长因子(EGF)在有丝分裂和增殖中的作用，它是寻找遗传多态的一个有趣的候选研究对象。广泛的研究发现，EGF基因的单核苷酸多态(SNP)+61G/A(Rs4444903)与胶质瘤的易感性有关，但其结果一直存在争议。此外，EGF+61G/A基因多态性与脑胶质瘤的发生发展和分级进展之间的关系尚未建立。我们通过荟萃分析研究了EGF+61G/A基因多态与脑胶质瘤的关系。共检索到9篇关于EGF+61G/A基因多态性与脑胶质瘤发病风险的研究，涉及1758例患者和2823例对照。优势比(OR)和95%可信区间(CI)被用来评估这种关联的强度。对等位基因模型、共显性模型、显性模型和隐性模型分别进行合并OR。总体而言，这项荟萃分析显示，在所有四种遗传模型中，EGF+61G/A多态与胶质瘤易感性显著相关。然而，在按胶质瘤分级进行的分层分析中，我们发现这种关联只存在于IV级胶质母细胞瘤患者中，而不存在于I-III级胶质瘤患者中。我们进一步比较了胶质母细胞瘤和I-III级胶质瘤患者的EGF+61G/A基因多态性，发现EGF+61G/A基因多态性与胶质瘤的恶性程度有较强的相关性。Meta分析结果提示，EGF+61G/A基因多态性与脑胶质瘤的易感性和恶性程度有关。
Gliomas account for almost 80% of primary malignant brain tumors. Epidermal growth factor (EGF) is an interesting research candidate in which to look for genetic polymorphisms because of its role in mitogenesis and proliferation. Extensive studies have found that a single nucleotide polymorphism (SNP) +61G/A (rs4444903) in the EGF gene is associated with the susceptibility of glioma, however, the results have been controversial. Furthermore, the association between EGF +61G/A polymorphism with the development and grade progress of glioma has not been established. We examined the association of EGF +61G/A polymorphism and glioma by performing a meta-analysis. Nine studies testing the associations between EGF +61G/A polymorphism and risk of glioma with 1758 cases and 2823 controls were retrieved. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for the allele model, codominant model, dominant model, and recessive model, respectively. Overall, this meta-analysis showed significant associations between the EGF +61G/A polymorphism and glioma susceptibility in all four genetic models. However, in the stratified analysis by the grade of glioma, we only found this association existed in patients with Grade IV glioblastoma, but not in patients with Grade I-III glioma. We further compared EGF +61G/A polymorphism in patients with glioblastoma and Grade I-III glioma accordingly, the stronger association between the EGF +61G/A polymorphism and the malignancy of glioma was found. The results of this meta-analysis suggested that the EGF +61G/A polymorphism is associated with both the susceptibility of glioma and the malignance of glioma.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
168.9
作者：
Ricard, Damien;Idbaih, Ahmed;Delattre, Jean-Yves
通讯作者：
Delattre, Jean-Yves
影响因子：
11.2
作者：
Bhowmick, DA;Zhuang, ZP;Weil, RJ
通讯作者：
Weil, RJ
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
11.5
作者：
Nicholas, M. Kelly;Lukas, Rimas V.;Salgia, Ravi
通讯作者：
Salgia, Ravi