Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania.
Protocol for a four parallel-arm, single-blind, cluster-randomised trial to assess the effectiveness of three types of dual active ingredient treated nets compared to pyrethroid-only long-lasting insecticidal nets to prevent malaria transmitted by pyrethroid insecticide-resistant vector mosquitoes in Tanzania.
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DOI：
10.1136/bmjopen-2020-046664
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发表时间：
2021-03-08
期刊：
影响因子：
2.9
通讯作者：
Protopopoff N
中科院分区：
文献类型：
--
作者：
Mosha JF;Kulkarni MA;Messenger LA;Rowland M;Matowo N;Pitt C;Lukole E;Taljaard M;Thickstun C;Manjurano A;Mosha FW;Kleinschmidt I;Protopopoff N
长效杀虫蚊帐的大规模推广导致许多撒哈拉以南非洲国家的疟疾负担大大减轻。这一进展受到疟疾媒介中广泛存在的杀虫剂耐药性的威胁。这项群组随机对照试验(c-RCT)比较了三种最有希望的双活性成分LLIN(Dual-AI LLIN)，在对拟除虫菊酯具有抗药性的区域，LLIN包含杀虫剂或杀虫剂增效剂的混合物与标准LLIN。一项四臂单盲c-RCT将评估三种类型双AI LIN的药效：(1)皇家卫队，组合两种杀虫剂，拟除虫菊酯和拟除虫菊酯；(2)拦截器G2，结合氯氰菊酯和α-氯氰菊酯；(3)Olyset Plus，结合增效剂胡椒基丁醚和拟除虫菊酯的LLIN；(4)Interceptor LN，包含拟除虫菊酯的标准LLIN作为唯一的AI。主要结果是6个月至14岁儿童的疟疾感染率和昆虫学接种率(EIR)，作为干预后24个月疟疾传播的标准衡量标准和成本效益。坦桑尼亚国家医学研究所、乞力马扎罗基督教医科大学学院、伦敦卫生和热带医学院以及渥太华大学的机构审查委员会获得了伦理审查委员会的批准。研究结果将通过向利益攸关方、当地社区领导人和相关国家和国际政策制定者的报告和介绍以及通过会议和同行评议出版物积极传播。NCT03554616。
The massive scale-up of long-lasting insecticidal nets (LLINs) has led to major reductions in malaria burden in many sub-Saharan African countries. This progress is threatened by widespread insecticide resistance among malaria vectors. This cluster-randomised controlled trial (c-RCT) compares three of the most promising dual active ingredients LLINs (dual-AI LLINs), which incorporate mixtures of insecticides or insecticide synergists to standard LLINs in an area of pyrethroid insecticide resistance. A four-arm, single-blinded, c-RCT will evaluate the effectiveness of three types of dual-AI LLINs (1) Royal Guard, combining two insecticides, pyriproxyfen and the pyrethroid alpha-cypermethrin; (2) Interceptor G2, combining chlorfenapyr and alpha-cypermethrin; (3) Olyset Plus, an LLIN combining a synergist, piperonyl butoxide and the pyrethroid permethrin, compared with; (4) Interceptor LN, a standard LLIN containing the pyrethroid alpha-cypermethrin as the sole AI. The primary outcomes are malaria infection prevalence in children aged 6 months–14 years and entomological inoculation rate (EIR), as a standard measure of malaria transmission at 24 months postintervention and cost-effectiveness. Ethical approval was received from the institutional review boards of the Tanzanian National Institute for Medical Research, Kilimanjaro Christian Medical University College, London School of Hygiene and Tropical Medicine, and University of Ottawa. Study findings will be actively disseminated via reports and presentations to stakeholders, local community leaders, and relevant national and international policy makers as well as through conferences, and peer-reviewed publications. NCT03554616.
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影响因子：
11.8
作者：
Asidi A;N'Guessan R;Akogbeto M;Curtis C;Rowland M
通讯作者：
Rowland M
影响因子：
2.7
作者：
Charlwood JD;Rowland M;Protopopoff N;Le Clair C
通讯作者：
Le Clair C
影响因子：
15.8
作者：
Katureebe A;Zinszer K;Arinaitwe E;Rek J;Kakande E;Charland K;Kigozi R;Kilama M;Nankabirwa J;Yeka A;Mawejje H;Mpimbaza A;Katamba H;Donnelly MJ;Rosenthal PJ;Drakeley C;Lindsay SW;Staedke SG;Smith DL;Greenhouse B;Kamya MR;Dorsey G
通讯作者：
Dorsey G
影响因子：
3.7
作者：
Kawada H;Dida GO;Ohashi K;Kawashima E;Sonye G;Njenga SM;Mwandawiro C;Minakawa N
通讯作者：
Minakawa N
影响因子：
3
作者：
Bayili, Koama;N'do, Severin;Diabate, Abdoulaye
通讯作者：
Diabate, Abdoulaye