Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response.
Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response.
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DOI：
10.1002/mrm.24846
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发表时间：
2014-05
影响因子：
3.3
通讯作者：
Mason, Ralph P.
中科院分区：
文献类型：
--
作者：
Hallac, Rami R.;Zhou, Heling;Pidikiti, Rajesh;Song, Kwang;Stojadinovic, Strahinja;Zhao, Dawen;Solberg, Timothy;Peschke, Peter;Mason, Ralph P.
检查BOLD（血氧水平依赖性）和TOLD（组织氧合水平依赖性）对比MRI评估肿瘤氧合和预测放射反应的潜在用途。在4.7T高氧气体呼吸激发期间，对Dunning R3327-AT 1大鼠前列腺肿瘤进行BOLD和TOLD MRI。将动物分成两组。在第1组（n=9）中，随后基于六氟苯报告分子的自旋晶格弛豫的19 F MRI提供了定量血氧测定用于比较。对于第2组大鼠（n=13），将30戈伊单次给药后的生长延迟与辐照前BOLD和TOLD评估进行比较。氧（100%O2）和碳源（CB; 95%O2/5%CO2）激发引起相似的BOLD、TOLD和pO 2反应。BOLD或R2* 响应与定量19 F pO 2测量值之间存在强相关性。TOLD反应呈总体趋势，相关性较弱。照射引起了显着的肿瘤生长延迟和肿瘤的TOLD和R1值的变化较大时，氧气呼吸表现出显着增加的肿瘤生长延迟。这些结果为氧敏感（BOLD/TOLD）MRI和肿瘤pO 2之间的关系提供了进一步的见解。此外，更大的增加R1反应高氧气体的挑战与更大的肿瘤生长延迟照射后。
To examine the potential use of BOLD (Blood Oxygenation Level Dependent) and TOLD (Tissue Oxygenation Level Dependent) contrast MRI to assess tumor oxygenation and predict radiation response. BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n=9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n=13) growth delay following a single dose of 30 Gy was compared with pre-irradiation BOLD and TOLD assessments. Oxygen (100%O2) and carbogen (CB; 95%O2/5%CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.
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