Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making.
Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making.
复制标题
寻求新奇与个人风险偏好以及决策过程中风险预测相关的大脑激活有关
DOI：
10.1038/srep10534
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发表时间：
2015-06-11
影响因子：
4.6
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Wang Y;Liu Y;Yang L;Gu F;Li X;Zha R;Wei Z;Pei Y;Zhang P;Zhou Y;Zhang X
新奇寻求（NS）是一种反映对新奇刺激的兴奋反应的人格特质。高NS通常预示着危险行为，如药物滥用。然而，NS和风险相关的认知过程之间的关系，包括个人风险偏好和与风险预测相关的大脑激活，仍然难以捉摸。在这项功能磁共振成像研究中，参与者完成了三维人格问卷测量NS和概率决策任务。使用数学模型，我们估计个人的风险偏好。通过功能磁共振成像确定与风险预测相关的大脑区域。NS评分与风险偏好呈正相关，与风险预测引起的右后岛（r-PI）、左前岛（l-AI）、右纹状体（r-striatum）和辅助运动区（SMA）的激活呈负相关。在这些脑区中，只有r-PI中与风险预测相关的激活在控制风险偏好的影响后与NS相关。静息状态下r-PI和r-striatum/l-AI之间的功能连接与NS呈负相关。我们的研究结果表明，高NS可能与较少的厌恶风险和r-PI起着重要的作用，在相关的风险预测NS。
Novelty seeking (NS) is a personality trait reflecting excitement in response to novel stimuli. High NS is usually a predictor of risky behaviour such as drug abuse. However, the relationships between NS and risk-related cognitive processes, including individual risk preference and the brain activation associated with risk prediction, remain elusive. In this fMRI study, participants completed the Tridimensional Personality Questionnaire to measure NS and performed a probabilistic decision making task. Using a mathematical model, we estimated individual risk preference. Brain regions associated with risk prediction were determined via fMRI. The NS score showed a positive correlation with risk preference and a negative correlation with the activation elicited by risk prediction in the right posterior insula (r-PI), left anterior insula (l-AI), right striatum (r-striatum) and supplementary motor area (SMA). Within these brain regions, only the activation associated with risk prediction in the r-PI showed a correlation with NS after controlling for the effect of risk preference. Resting-state functional connectivity between the r-PI and r-striatum/l-AI was negatively correlated with NS. Our results suggest that high NS may be associated with less aversion to risk and that the r-PI plays an important role in relating risk prediction to NS.
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影响因子：
7.3
作者：
Chen, WJ;Chen, HM;Cheng, ATA
通讯作者：
Cheng, ATA
影响因子：
2.3
作者：
CLONINGER, CR;PRZYBECK, TR;SVRAKIC, DM
通讯作者：
SVRAKIC, DM
影响因子：
5.4
作者：
BELL, DE
通讯作者：
BELL, DE
影响因子：
3.7
作者：
McMurray MS;Amodeo LR;Roitman JD
通讯作者：
Roitman JD
影响因子：
2.9
作者：
Fan J
通讯作者：
Fan J