Membrane property changes in most distal motor axons in chronic inflammatory demyelinating polyneuropathy
Membrane property changes in most distal motor axons in chronic inflammatory demyelinating polyneuropathy
复制标题
慢性炎症性脱髓鞘性多发性神经病中大多数远端运动轴突的膜特性变化
DOI：
10.1002/mus.26744
复制
发表时间：
2019
期刊：
影响因子：
3.4
通讯作者：
Kuwabara Satoshi
中科院分区：
文献类型：
--
作者：
Amino Hiroshi;Shibuya Kazumoto;Misawa Sonoko;Sekiguchi Yukari;Beppu Minako;Suichi Tomoki;Suzuki Yo‐ichi;Tsuneyama Atsuko;Kuwabara Satoshi
在免疫介导的神经病变中，血神经屏障在解剖学上缺陷的远端神经末梢优先受到影响。方法对20例典型慢性炎症性脱髓鞘性多发性神经病（CIDP）患者进行尺神经运动点和腕部的运动神经兴奋性测定，结果慢性炎性脱髓鞘性多发性神经病患者的阈值变化明显大于正常人。运动点的超极化阈值电紧张（P<0.05），但在腕部没有。强度-持续时间常数没有显示CIDP和对照组在两个sites.DiscussionAxonal属性的变化CIDP更突出的轴突的远端部分相比，神经干，大概是由于突出的脱髓鞘远端神经末梢附近。运动点兴奋性测量可以阐明免疫介导的神经病变的基础病理生理学。
IntroductionDistal nerve terminals, where the blood‐nerve barrier is anatomically deficient, are preferentially affected in immune‐mediated neuropathies. Excitability alterations near the motor nerve terminals may be more prominent than the nerve trunk in typical chronic inflammatory demyelinating polyneuropathy (CIDP).MethodsIn 20 patients with typical CIDP, motor nerve excitability testing was performed at the motor point and wrist of the ulnar nerve, and results were compared with those in 20 healthy persons.ResultsChronic inflammatory demyelinating polyneuropathy patients showed greater threshold changes in hyperpolarizing threshold electrotonus at the motor point (P< .05) but not at the wrist. Strength‐duration time constant did not show significant differences between CIDP and controls at both sites.DiscussionAxonal property changes in CIDP are more prominent in distal portions of axons compared with the nerve trunk, presumably due to salient demyelination near the distal nerve terminals. Motor point excitability measurements could elucidate underlying pathophysiology in immune‐mediated neuropathies.
登录
查看更多内容
影响因子：
11.2
作者：
Shibuya, Kazumoto;Sugiyama, Atsuhiko;Kuwabara, Satoshi
通讯作者：
Kuwabara, Satoshi
影响因子：
11
作者：
Kuwabara, S;Ogawara, K;Hattori, T
通讯作者：
Hattori, T
在运动点测量的人类中位轴突的兴奋性特性
影响因子：
3.4
作者：
S. Kuwabara;H. Bostock;K. Ogawara;J. Sung;S. Misawa;Yukiko Kitano;K. Mizobuchi;C. Lin;T. Hattori
通讯作者：
T. Hattori
影响因子：
4.7
作者：
Attarian, S;Azulay, JP;Pouget, J
通讯作者：
Pouget, J
影响因子：
--
作者：
Lin, Cindy Shin-Yi;Krishnan, Arun V.;Kiernan, Matthew C.
通讯作者：
Kiernan, Matthew C.