Enhanced Accumulation of Colloidal Particles in Microgrooved Channels via Diffusiophoresis and Steady-State Electrolyte Flows.
Enhanced Accumulation of Colloidal Particles in Microgrooved Channels via Diffusiophoresis and Steady-State Electrolyte Flows.
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DOI：
10.1021/acs.langmuir.2c01755
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发表时间：
2022-11-22
期刊：
影响因子：
3.9
通讯作者：
Bolognesi, Guido
中科院分区：
文献类型：
--
作者：
Singh, Naval;Vladisavljevic, Goran T.;Nadal, Francois;Cottin-Bizonne, Cecile;Pirat, Christophe;Bolognesi, Guido
在死端微结构中输送胶体颗粒是非常具有挑战性的，因为这些几何形状不允许载有颗粒的流体的净流动;同时，扩散输送缓慢且效率低下。最近，我们介绍了一种基于扩散电泳的新型粒子操作策略，由此微槽通道中平行电解质流之间的盐浓度梯度诱导快速（即，几分钟内）和微槽中胶体颗粒的可逆积累、保留和去除。在这项研究中，我们调查的盐对比度和凹槽深度的影响，在硅微槽的积累过程中，并确定实验条件，导致超过四倍的浓度在通道散装的颗粒浓度峰值。此外，我们实现了槽中的平均颗粒浓度是流动流中浓度的两倍以上，并且比在没有盐浓度梯度的情况下槽中的平均浓度大几乎2个数量级。分析的充分和必要条件的颗粒积累。最后，我们成功地测试了聚二甲基硅氧烷微槽通道中的积累过程，因为它们比硅微槽衬底制造成本更低。通过溶质浓度梯度控制和增强胶体颗粒在死端结构中的积累在软物质和生命系统中具有潜在的应用，例如药物递送、合成生物学和芯片诊断。
The delivery of colloidal particles in dead-end microstructures is very challenging, since these geometries do not allow net flows of particle-laden fluids; meanwhile, diffusive transport is slow and inefficient. Recently, we introduced a novel particle manipulation strategy, based on diffusiophoresis, whereby the salt concentration gradient between parallel electrolyte streams in a microgrooved channel induces the rapid (i.e., within minutes) and reversible accumulation, retention, and removal of colloidal particles in the microgrooves. In this study, we investigated the effects of salt contrast and groove depth on the accumulation process in silicon microgrooves and determined the experimental conditions that lead to a particle concentration peak of more than four times the concentration in the channel bulk. Also, we achieved an average particle concentration in the grooves of more than twice the concentration in the flowing streams and almost 2 orders of magnitude larger than the average concentration in the grooves in the absence of a salt concentration gradient. Analytical sufficient and necessary conditions for particle accumulation are also derived. Finally, we successfully tested the accumulation process in polydimethylsiloxane microgrooved channels, as they are less expensive to fabricate than silicon microgrooved substrates. The controlled and enhanced accumulation of colloidal particles in dead-end structures by solute concentration gradients has potential applications in soft matter and living systems, such as drug delivery, synthetic biology, and on-chip diagnostics.
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影响因子：
3.4
作者：
Huff M
通讯作者：
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影响因子：
16.6
作者：
Friedrich SM;Burke JM;Liu KJ;Ivory CF;Wang TH
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影响因子：
41.2
作者：
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通讯作者：
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