Getting started with open-hardware: development and control of microfluidic devices.
Getting started with open-hardware: development and control of microfluidic devices.
复制标题
DOI：
10.1002/elps.201400128
复制
发表时间：
2014-08
期刊：
影响因子：
2.9
通讯作者：
Garcia, Carlos D.
中科院分区：
文献类型：
--
作者：
da Costa, Eric Tavares;Mora, Maria F.;Willis, Peter A.;do Lago, Claudimir L.;Jiao, Hong;Garcia, Carlos D.
了解电子和计算机编程的基本概念，使研究人员能够最大限度地利用实验室中的设备。虽然许多平台是专门为公众设计的，并且有大量的在线教程支持，但这一主题通常不包括在大学化学课程中。本文旨在提供硬件和软件的基本概念，重点设计和使用一个简单的模块来控制一系列基于pdm的阀门。该模块基于低成本微处理器（Teensy）和开源软件（Arduino）。微阀是用PDMS薄板制造的，并使用CO2激光雕刻来制作图案，提供了一种简单有效的方法来制造设备，而不需要传统的光刻工艺或设备。阀门控制的同步化使两个简单的装置能够进行注射（1.6±0.4 μL/冲程）和不同溶液的混合。此外，该系统在微尺度化学样品处理和分析方面的实际应用得到了验证，包括芯片上的酸碱滴定，以及利用开源的低成本检测系统进行电导率检测。总的来说，该系统提供了一个非常可重复性（98%）的平台，可以在微流体规模下进行流体输送。
Understanding basic concepts of electronics and computer programming allows researchers to get the most out of the equipment found in their laboratories. Although a number of platforms have been specifically designed for the general public and are supported by a vast array of on-line tutorials, this subject is not normally included in university chemistry curricula. Aiming to provide the basic concepts of hardware and software, this article is focused on the design and use of a simple module to control a series of PDMS-based valves. The module is based on a low-cost microprocessor (Teensy) and open-source software (Arduino). The microvalves were fabricated using thin sheets of PDMS and patterned using CO2 laser engraving, providing a simple and efficient way to fabricate devices without the traditional photolithographic process or facilities. Synchronization of valve control enabled the development of two simple devices to perform injection (1.6 ± 0.4 μL/stroke) and mixing of different solutions. Furthermore, a practical demonstration of the utility of this system for microscale chemical sample handling and analysis was achieved performing an on-chip acid-base titration, followed by conductivity detection with an open-source low-cost detection system. Overall, the system provided a very reproducible (98%) platform to perform fluid delivery at the microfluidic scale.
登录
查看更多内容
影响因子：
2.9
作者：
Felhofer, Jessica L.;Blanes, Lucas;Garcia, Carlos D.
通讯作者：
Garcia, Carlos D.
影响因子：
8.4
作者：
Grover, WH;Skelley, AM;Mathies, RA
通讯作者：
Mathies, RA
DOI：
10.1016/j.ijmedinf.2013.04.001
发表时间：
2013-08-01
影响因子：
4.9
作者：
Marsan, Josianne;Pare, Guy
通讯作者：
Pare, Guy
影响因子：
--
作者：
Jensen, Erik C.;Zeng, Yong;Kim, Jungkyu;Mathies, Richard A.
通讯作者：
Mathies, Richard A.
影响因子：
1.6
作者：
Jobbins, Matthew M.;Raigoza, Annette F.;Kandel, S. Alex
通讯作者：
Kandel, S. Alex