The effect of periosteal injury and masticatory micromovement on the healing of a mandibular distraction osteogenesis site.
The effect of periosteal injury and masticatory micromovement on the healing of a mandibular distraction osteogenesis site.
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DOI：
10.1016/j.archoralbio.2008.12.002
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发表时间：
2009-03
影响因子：
3
通讯作者：
Herring, Susan W.
中科院分区：
文献类型：
--
作者：
Sun, Zongyang;Herring, Susan W.
手术骨膜损伤和咀嚼负荷可能是影响下颌骨DO部位愈合的因素。本研究旨在描述早期下颌骨DO部位的愈合特征，并评估这些因素的影响。18只3-6月龄小型猪接受右下颌骨截骨术，并牵引5天（1 mm/天），巩固0、1或2周（分别为A、B和C组）。采用组织学方法测量牵张部位的骨形成、软骨形成和血管结构，并表征其随巩固时间的变化。骨膜损伤的影响通过比较损伤较严重的外侧与受干扰较少的内侧来评估。咀嚼负荷的影响进行了评估有关的愈合功能的interfragmental微运动所造成的软饮食咀嚼。随着巩固时间的延长，骨形成和软骨形成逐渐增强，血管结构逐渐成熟。与内侧相比，A组和B组外侧的骨形成和软骨形成明显延迟，但C组没有，其中发生了骨膜恢复。内侧和外侧之间的血管测量值无差异。在组B中，骨形成，而不是软骨形成或血管结构，往往与牵张阶段咀嚼微动的幅度呈负相关。结果表明，骨膜损伤抑制早期下颌骨DO网站愈合，而软饮食咀嚼力学的微运动具有微不足道的影响。
Surgical periosteal injury and masticatory loading are likely factors affecting the healing of a mandibular DO site. This study is aimed to characterize the healing features of an early-phase mandibular DO site and assess the effects of these factors. Eighteen 3–6 month-old miniature pigs received a right mandibular osteotomy and were distracted for 5 days (1 mm/day) and consolidated for 0, 1 or 2 weeks (Groups A, B and C, respectively). Bone formation, chondrogenesis and vascular structure of the distraction site were measured using histological methods and their changes with consolidation time were characterized. The effect of periosteal injury was assessed by comparing the more severely injured lateral side with the less disturbed medial side. The effect of masticatory loading was evaluated by relating the healing features to the interfragmentary micromovement caused by soft-diet mastication. With consolidation time, bone formation and chondrogenesis became stronger while vascular structure became more mature. Compared to the medial side, bone formation and chondrogenesis on the lateral side were significantly delayed in Groups A and B, but not in Group C, in which periosteal recovery had occurred. No difference was found for vascular measurements between the medial and lateral sides. In Group B, bone formation, but not chondrogenesis or vascular structures, tended to be negatively correlated with the magnitude of masticatory micromovement during the distraction phase. The results suggest that periosteal injury inhibits early mandibular DO site healing, whereas micromovement from soft-diet mastication mechanics has a negligible effect.
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影响因子：
0.9
作者：
Bauer, Stephen M;Bauer, Richard J;Velazquez, Omaida C
通讯作者：
Velazquez, Omaida C
DOI：
10.1097/01.blo.0000150562.24256.a4
发表时间：
2005-04-01
影响因子：
4.2
作者：
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作者：
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影响因子：
3.6
作者：
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通讯作者：
Walsh, WR
影响因子：
3.6
作者：
Glowacki, J;Shusterman, EM;Kaban, LB
通讯作者：
Kaban, LB