Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice.
Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice.
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DOI：
10.1038/tp.2012.83
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发表时间：
2012-08-28
影响因子：
6.8
通讯作者：
D'Amato FR
中科院分区：
文献类型：
--
作者：
Cinque C;Pondiki S;Oddi D;Di Certo MG;Marinelli S;Troisi A;Moles A;D'Amato FR
社交快感缺乏，或从社会归属中体验快乐和奖励的能力下降，是不同精神疾病的主要症状，包括某些形式的婴儿自闭症和精神分裂症谱系障碍。社会依恋的大脑阿片类药物假说是一个很有前途的模型，可以深入了解神经生物学和发育因素如何影响社会奖励的调节。在这项研究中，在出生后的前 4 天使用基因敲除和纳曲酮 (NTRX) 治疗来破坏小鼠幼崽的阿片类神经传递及其与母亲的依恋关系。阿片类神经传递的永久性（遗传）和暂时（药理学）操作都会对社会归属感产生长期影响。在青少年时期，μ-阿片受体敲除小鼠和 NTRX 治疗的幼崽都表现出对同伴的兴趣降低，并且对社会奖励环境没有偏好。这些结果表明，幼年小鼠的社交能力高度依赖于在婴儿期与母亲建立积极的情感关系，并且阿片类神经传递在社交享乐能力的调节中发挥着重要作用。如果未来的研究能够证实这种动物模型的有效性，那么关注早期经历和阿片类神经传递之间相互作用的转化研究可以为识别与社交快感缺乏相关的人类精神疾病的内表型提供有用的见解。
Social anhedonia, or the diminished capacity to experience pleasure and reward from social affiliation, is a major symptom of different psychiatric disorders, including some forms of infantile autism and schizophrenia spectrum disorders. The brain opioid hypothesis of social attachment is a promising model for achieving insights into how neurobiological and developmental factors contribute to the regulation of social reward. In this study, genetic knocking-out and naltrexone (NTRX) treatment during the first 4 days of life were used to disrupt opioid neurotransmission in mouse pups and their attachment relationships with the mother. Both permanent (genetic) and transient (pharmacological) manipulations of opioid neurotransmission exerted long-term effects on social affiliation. When juveniles, both μ-opioid receptor knockout mice and NTRX-treated pups showed reduced interest in peers and no preference for socially rewarding environment. These results demonstrate that sociability in juvenile mice is highly dependent on the establishment during infancy of a positive affective relationship with their mothers and that opioid neurotransmission has a major role in the regulation of social hedonic capacity. If the validity of this animal model will be confirmed by future research, translational studies focusing on the interaction between early experience and opioid neurotransmission could provide useful insights for identifying endophenotypes of human psychiatric disorders associated with social anhedonia.
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DOI：
10.1111/j.1749-6632.2009.04541.x
发表时间：
2009-01-01
期刊：
VALUES, EMPATHY, AND FAIRNESS ACROSS SOCIAL BARRIERS
影响因子：
--
作者：
Ebstein, Richard P.;Israel, Salomon;Yirmiya, Nurit
通讯作者：
Yirmiya, Nurit
影响因子：
64.8
作者：
Matthes, HWD;Maldonado, R;Kieffer, BL
通讯作者：
Kieffer, BL
社交厌恶症是精神分裂症谱系障碍发展的一个预测因素
影响因子：
4.6
作者：
Kwapil, TR
通讯作者：
Kwapil, TR
影响因子：
8.2
作者：
Brown, Leslie H.;Silvia, Paul J.;Kwapil, Thomas R.
通讯作者：
Kwapil, Thomas R.
影响因子：
11
作者：
Harvey, P-O;Pruessner, J.;Lepage, M.
通讯作者：
Lepage, M.