Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme-1-year result.
Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme-1-year result.
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中国多中心新生儿眼部筛查项目早期发现眼部异常——一年结果
DOI：
10.1111/aos.14586
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发表时间：
2021-05
影响因子：
3.4
通讯作者：
Zhao P
中科院分区：
文献类型：
--
作者：
Fei P;Liu Z;He L;Li N;Xu L;Zhang M;Zhou Y;Li F;Wang H;Zhang Q;Huang Q;Li Y;Chen S;Guo W;Li Y;Liu Y;Lu J;Wang Y;Zhu X;Wang L;Wang Y;Xian J;Xu Y;Ji X;Liang T;Ren J;Zhang X;Li J;Zhao P
早期发现新生儿眼部异常对于及时诊断和治疗至关重要。本研究旨在评估中国使用大视场数字成像系统的多中心前瞻性新生儿眼科检查项目1年的结果。2016年7月至2017年6月，在全国9家医院（包括8家妇幼医院和1家综合医院）建立了新生儿眼科筛查的多中心合作前瞻性研究组。使用宽视场数字成像系统对出生后28天内的新生儿进行眼部检查。对数据进行了审查和分析。主要结果是新生儿眼部异常的发生率。64 632例新生儿中检出异常13 514例，占20.91%。最常见的异常是视网膜出血（RH; 11.83%）。大多数轻度RH自行消退。在超过中国早产儿视网膜病变（ROP）筛查标准（胎龄≥32 w，出生体重≥2000 g）的新生儿中，有眼部异常的新生儿总数为12 218/62 799（19.45%）。59.44%的新生儿眼部异常（占所有筛查人群的11.56%）需要进一步干预或观察。其中258例（占全部筛查人群的0.41%）需要立即或及时干预，包括先天性白内障、视网膜脱离、视网膜母细胞瘤等眼部异常。198例患者（占所有筛查新生儿的1.75%）应密切随访，必要时需要进一步诊断或干预，如ROP或ROP样视网膜病变、家族性渗出性玻璃体视网膜病变和原发性玻璃体持续性增生。临床意义轻微的5900例（9.4%）患者需要短期随访。这项前瞻性的多中心新生儿眼部检查研究显示了相对较高的眼部异常患病率。在那些没有进行常规筛查的新生儿中，有较高比例的先天性眼病需要进一步转诊和治疗。根据新生儿眼部检查的益处和风险，新生儿眼部筛查方案可以在早期发现眼部异常，并可能在促进儿童眼部健康方面发挥积极作用。
Early detection of ocular abnormalities in newborns is essential for timely diagnosis and treatment. This study aimed to assess the 1‐year result of a multicentre prospective neonatal eye examination programme with wide‐field digital imaging system in China. A multicentre collaborative prospective study group for neonatal eye screening was established in nine hospitals, including eight Maternal and Children's Hospitals, and one general hospital across China from July 2016 to June 2017. Ocular examinations were performed on newborns within 28 days after birth using a wide‐field digital imaging system. Data were reviewed and analysed. The primary outcome was the prevalence of ocular abnormalities in neonates. We detected 13 514 (20.91%) abnormal cases in 64 632 newborns. The most frequent abnormality was retinal haemorrhage (RH; 11.83%). Most of mild RH resolved spontaneously. Among those who were beyond retinopathy of prematurity (ROP) screening criteria of China (gestational age ≥32 w and birthweight ≥2000 g), the total number of neonates with ocular abnormality was 12 218/62 799(19.45%). 59.44% of neonatal ocular abnormalities detected (accounting for 11.56% of all the screened population) needed further interference or observation. Among them, 258 patients (0.41% of all the screened population) needed immediate or timely intervention, including congenital cataract, retinal detachment, retinoblastoma and other ocular abnormalities. One thousand and ninety‐eight patients (1.75% of all the screened neonates) should be followed up closely and needed further diagnosis or intervention if necessary, such as ROP or ROP‐like retinopathy, familial exudative vitreoretinopathy and persistent hyperplasia of primary vitreous. Five thousand nine hundred and six patients (9.4%) with minor clinical significance needed short‐term follow‐up. This prospective multicentre study of newborn ocular examination showed a relatively high prevalence of ocular abnormalities. There are a relatively high percentage of congenital eye pathology that required further referral and treatment in those neonates who were not screened routinely. According to the benefits and risks associated with neonatal eye examinations, neonatal ocular screening programme can detect ocular abnormalities at the very early stage and may play a positive role in promoting paediatric eye health.
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影响因子：
5.1
作者：
Sun, Ming;Ma, Aihua;Zhao, Bojun
通讯作者：
Zhao, Bojun
影响因子：
13.7
作者：
Callaway NF;Ludwig CA;Blumenkranz MS;Jones JM;Fredrick DR;Moshfeghi DM
通讯作者：
Moshfeghi DM
DOI：
10.1097/00006982-198400420-00004
发表时间：
1984-01-01
影响因子：
3.3
作者：
VONFRICKEN, MA;DHUNGEL, R
通讯作者：
DHUNGEL, R
影响因子：
3.9
作者：
Goyal, P.;Padhi, T. R.;Jalali, S.
通讯作者：
Jalali, S.
影响因子：
2
作者：
Ma Y;Deng G;Ma J;Liu J;Li S;Lu H
通讯作者：
Lu H