Gene expression during the oocyte-to-embryo transition in mammals.
Gene expression during the oocyte-to-embryo transition in mammals.
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DOI：
10.1002/mrd.21038
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
de Evsikova, Caralina Marin
中科院分区：
文献类型：
--
作者：
Evsikov, Alexei V.;de Evsikova, Caralina Marin
现代发育生物学中的一个重要问题是精子和卵子结合产生的新生命的起源。这个问题的根源开始于19 - 20世纪世纪胚胎学家对受精和胚胎发生的研究。虽然分子生物学的革命已经对这一过程的复杂性产生了重要的见解，但基因，分子和细胞的整体编排仍然没有完全形成。早期哺乳动物的发育，特别是卵母细胞到胚胎的转变，基本上是在“母亲的命令”从卵母细胞生长过程中沉积在细胞质中的因素，独立于新生胚胎的从头转录。在理解这一发展时期的许多进展是与分子生物学新方法和新技术的应用相结合的，从蛋白质电泳到测序和整个基因组的组装。从这一基础知识来看，mRNA翻译的精确控制似乎是协调卵母细胞向胚胎过渡期间发生的分子和细胞事件的关键调节因子。值得注意的是，卵母细胞转录组共享，但保留一些独特性，共同的遗传基序之间的所有脊索动物。共同的遗传基序通常定义了细胞维持的关键基本过程，而独特的遗传特征可能是变异的来源，也是性选择、遗传漂变或基因流动的基质。基因、蛋白质和细胞之间这种复杂的相互作用的一个目的可能是允许进化在分子、结构和生物体水平上改变和作用于潜在的过程，以增加多样性，这是有性生殖的最终目标。
The seminal question in modern developmental biology is the origins of new life arising from the unification of sperm and egg. The roots of this question begin from 19th-20th century embryologists studying fertilization and embryogenesis. Although the revolution of molecular biology has yielded significant insight into the complexity of this process, the overall orchestration of genes, molecules, and cells, is still not fully formed. Early mammalian development, specifically the oocyte-to-embryo transition, is essentially under “maternal command” from factors deposited in the cytoplasm during oocyte growth, independent of de novo transcription from the nascent embryo. Many of the advances in understanding this developmental period occurred in tandem with application of new methods and techniques from molecular biology, from protein electrophoresis to sequencing and assemblies of whole genomes. From this bed of knowledge, it appears that precise control of mRNA translation is a key regulator coordinating the molecular and cellular events occurring during oocyte-to-embryo transition. Notably, oocyte transcriptomes share, yet retain some uniqueness, common genetic motifs among all chordates. The common genetic motifs typically define fundamental processes critical for cellular maintenance, whereas the unique genetic features may be a source of variation and a substrate for sexual selection, genetic drift, or gene flow. One purpose for this complex interplay among genes, proteins, and cells may allow for evolution to transform and act upon the underlying processes, at molecular, structural and organismal levels, to increase diversity, which is the ultimate goal of sexual reproduction.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
DOI：
10.1073/pnas.81.15.4860
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BLACKBURN, DG;VITT, LJ;BEUCHAT, CA
通讯作者：
BEUCHAT, CA
影响因子：
14.9
作者：
Blake JA;Bult CJ;Eppig JT;Kadin JA;Richardson JE;Mouse Genome Database Group
通讯作者：
Mouse Genome Database Group
影响因子：
3.5
作者：
Adjaye, J;Bolton, V;Monk, M
通讯作者：
Monk, M
影响因子：
1.9
作者：
Adjaye, J
通讯作者：
Adjaye, J