Prospecting Human Milk Oligosaccharides as a Defense Against Viral Infections.
Prospecting Human Milk Oligosaccharides as a Defense Against Viral Infections.
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DOI：
10.1021/acsinfecdis.0c00807
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发表时间：
2021-02-12
影响因子：
5.3
通讯作者：
Townsend SD
中科院分区：
文献类型：
--
作者：
Moore RE;Xu LL;Townsend SD
除了为新生儿的生长和发育提供最大的营养价值外，母乳还可以作为一种早期防御机制来抵御入侵的病原体。人乳低聚糖(HMOS)广泛存在于人乳中，是一类具有广泛保护作用的非均相碳水化合物。除了促进有益的肠道菌群的定植外，HMOS还充当诱饵受体，有效地阻止病原菌和病毒的附着。HMOS还起到抑菌剂的作用，抑制革兰氏阳性细菌的生长。基于这一先例，该领域的一个新兴领域集中在表征HMOS的抗病毒特性上。事实上，已经对HMO作为抗病毒药物的潜力进行了评估，许多药物被证明具有对抗危及生命的感染的活性。这篇有针对性的综述为部分HMO与流感、轮状病毒、呼吸道合胞病毒(RSV)、人类免疫缺陷病毒(HIV)和诺如病毒之间的已知糖链结合相互作用提供了洞察力。此外，我们回顾了HMOS在预防坏死性小肠结肠炎(NEC)中的作用，NEC是一种与病毒感染有关的肠道疾病。我们最后讨论了已知的关于母乳低聚糖及其与冠状病毒相互作用的广泛情况。
In addition to providing maximal nutritional value for neonatal growth and development, human milk functions as an early defense mechanism against invading pathogens. Human milk oligosaccharides (HMOs), which are abundant in human milk, are a diverse group of heterogeneous carbohydrates with wide ranging protective effects. In addition to promoting the colonization of beneficial intestinal flora, HMOs serve as decoy receptors, effectively blocking the attachment of pathogenic bacteria and viruses. HMOs also function as bacteriostatic agents, inhibiting the growth of gram-positive bacteria. Based on this precedence, an emerging area in the field has focused on characterizing the antiviral properties of HMOs. Indeed, HMOs have been evaluated for their potential as antiviral agents, with many shown to possess activity against life-threatening infections. This targeted review provides insight to the known glycan-binding interactions between select HMOs and influenza, rotavirus, respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), and norovirus. Additionally, we review the role of HMOs in preventing necrotizing enterocolitis (NEC), an intestinal disease linked to viral infections. We close with a discussion of what is known, broadly regarding human milk oligosaccharides and their interactions with coronaviruses.
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影响因子：
5.3
作者：
Ackerman DL;Craft KM;Doster RS;Weitkamp JH;Aronoff DM;Gaddy JA;Townsend SD
通讯作者：
Townsend SD
DOI：
10.1038/nrmicro975
发表时间：
2004-09
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
De Clercq E
通讯作者：
De Clercq E
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
Morrow, Ardythe L.
DOI：
10.1093/bioinformatics/btz814
发表时间：
2020-03-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Southgate JA;Bull MJ;Brown CM;Watkins J;Corden S;Southgate B;Moore C;Connor TR
通讯作者：
Connor TR
影响因子：
24.5
作者：
Autran, Chloe A.;Kellman, Benjamin P.;Bode, Lars
通讯作者：
Bode, Lars