The evolutionary processes of canine coronaviruses.

The evolutionary processes of canine coronaviruses.
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DOI:
10.1155/2011/562831
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发表时间:
2011
影响因子:
2.2
通讯作者:
Pratelli A
Pratelli A
中科院分区:
其他
文献类型:
--
作者:
Pratelli A

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自1971年首次发现该病毒以来,由犬冠状病毒(CCoV)引起的疾病尚未得到充分研究,该病毒在犬肠道疾病中的作用尚未得到充分确定。直到2002年SARS在人类中出现后,冠状病毒才引起了新的关注。由于RNA阳性链病毒的相对高的突变频率,CCoV已经进化,并且随着过去二十年中开发的生物分子技术,已经在感染的狗中鉴定出新的病毒株、血清型和亚型。考虑到犬群中CCoV感染的广泛性,已经进行了几项研究,重点是这些病毒的流行病学相关性,并强调需要进一步调查CCoV的生物学和感染的致病作用。本文报道了CCoV的进化过程,并对最近的诊断方法进行了说明。
Since the first identification of the virus in 1971, the disease caused by canine coronavirus (CCoV) has not been adequately investigated, and the role that the virus plays in canine enteric illness has not been well established. Only after the emergence in 2002 of SARS in human has new attention been focused on coronaviruses. As a consequence of the relatively high mutation frequency of RNA-positive stranded viruses, CCoV has evolved and, with the biomolecular techniques developed over the last two decades, new virus strains, serotypes, and subtypes have been identified in infected dogs. Considering the widespread nature of CCoV infections among dog populations, several studies have been carried out, focusing upon the epidemiological relevance of these viruses and underlining the need for further investigation into the biology of CCoVs and into the pathogenetic role of the infections. This paper reports the evolutionary processes of CCoVs with a note onto recent diagnostic methods.
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