Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China.
Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China.
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DOI：
10.1038/s41598-020-74244-0
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发表时间：
2020-10-13
影响因子：
4.6
通讯作者：
Suzuki T
中科院分区：
文献类型：
--
作者：
Zhou X;Nakashima K;Ito M;Zhang X;Sakai S;Feng C;Sun H;Chen H;Li TC;Suzuki T
人多瘤病毒（PyV）和肝炎病毒通常在人免疫缺陷病毒（HIV）感染者中更流行或更持久，并且相关疾病比免疫活性个体中更丰富。在这里，我们评估了联合抗逆转录病毒治疗（cART）时代中国HIV/AIDS患者和普通人群中人类PyV和肝炎病毒的血清反应性和病毒载量。共招募了810名HIV-1感染患者和年龄和性别匹配的HIV阴性个体，以评估PyV BKPyV、JCPyV、MCPyV、TSPyV和NJPyV以及肝炎病毒HBV、HCV和HEV的血清阳性率。583例（72%）接受cART治疗，其中31.2%的患者检测不到HIV RNA。HIV阳性组和阴性组的抗PyV抗体阳性率无显著差异，但HIV阳性组的血清DNA阳性率和MCPyV的DNA拷贝数均较高。在HIV感染患者中，CD 4+细胞计数< 200个细胞/mm 3的患者BKPyV DNA阳性率显着高于CD 4+细胞计数> 500个细胞/mm 3的患者，这表明可能是HIV诱导的免疫抑制引起的再激活。HIV阳性组中HBV和HCV血清阳性率较高，但HEV血清阳性率不高。进一步的相关性分析表明，HBV和HEV是PyV感染率增加的潜在危险因素。
Human polyomaviruses (PyVs) and hepatitis viruses are often more prevalent or persistent in human immunodeficiency virus (HIV)-infected persons and the associated diseases are more abundant than in immunocompetent individuals. Here, we evaluated seroreactivities and viral loads of human PyVs and hepatitis viruses in HIV/AIDS patients and the general population in China in the combination antiretroviral therapy (cART) era. A total of 810 HIV-1-infected patients and age- and sex-matched HIV-negative individuals were enrolled to assess seroprevalence of PyVs BKPyV, JCPyV, MCPyV, TSPyV, and NJPyV and hepatitis viruses HBV, HCV, and HEV. 583 (72%) patients received cART, and among them, 31.2% had undetectable HIV RNA. While no significant difference was observed in prevalence of anti-PyV antibodies between HIV-positive and -negative groups, serum DNA positivity and DNA copy level of MCPyV were higher in the HIV-positive group. Among HIV-infected patients, BKPyV DNA positivity was significantly higher in patients with CD4 + cell counts < 200 cells/mm3 compared to those with CD4 + cell counts > 500 cells/mm3, suggesting possible reactivation caused by HIV-induced immune suppression. Higher HBV and HCV seropositivities but not HEV seropositivity were also observed in the HIV-positive group. Further correlation analyses demonstrated that HBV and HEV are potential risk factors for increased prevalence of PyV infection.
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影响因子：
6
作者：
Xie, Jing;Han, Yang;Li, Taisheng
通讯作者：
Li, Taisheng
影响因子：
2.5
作者：
Ding, Y.;Duan, S.;He, N.
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168.9
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Engels, EA;Frisch, M;Miller, RW
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Gaboriaud P;Ferté M;Arnold F;Leblond V;Nicol J;Debare H;Le Meur M;Martini F;Tognon M;Touzé A
通讯作者：
Touzé A
影响因子：
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作者：
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