Pallidal stimulation that improves parkinsonian motor symptoms also modulates neuronal firing patterns in primary motor cortex in the MPTP-treated monkey.
Pallidal stimulation that improves parkinsonian motor symptoms also modulates neuronal firing patterns in primary motor cortex in the MPTP-treated monkey.
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DOI：
10.1016/j.expneurol.2009.04.022
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发表时间：
2009-09
影响因子：
5.3
通讯作者：
McIntyre, Cameron C.
中科院分区：
文献类型：
--
作者：
Johnson, Matthew D.;Vitek, Jerrold L.;McIntyre, Cameron C.
深部脑刺激(DBS)是一种治疗晚期帕金森病(PD)的外科疗法，已知会改变苍白球丘脑回路中的神经元活动模式。这些效应是否会转化到运动皮质，如果是的话，它们可能如何调节初级运动皮质中单个神经元的功能反应仍不确定。用1-甲基-4-苯基-1，2，3，6-四氢吡啶(MPTP)处理猴，植入跨越苍白球内外节段的DBS导线。在针对强直和运动迟缓的治疗性刺激(135 Hz)中，初级运动皮质(M1)的神经元对刺激表现出抑制锁相(2-5ms)，平均放电率总体下降，对被动肢体运动的反应特异性增加。亚治疗性DBS(30 Hz)对刺激仍有夹带作用，但平均放电率和运动特异性没有改变。较低的刺激强度(135赫兹)不再改善运动症状，对M1活动几乎没有影响。这些发现表明，DBS通过诱导苍白球-丘脑皮质感觉运动回路的整体放电模式和频率的改变来改善帕金森氏症的运动症状。
Deep brain stimulation (DBS), a surgical therapy for advanced Parkinson's disease (PD), is known to change neuronal activity patterns in the pallidothalamic circuit. Whether these effects translate to motor cortex and, if so, how they might modulate the functional responses of individual neurons in primary motor cortex remains uncertain. A 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkey was implanted with a DBS lead spanning internal and external segments of globus pallidus. During therapeutic stimulation (135 Hz) for rigidity and bradykinesia, neurons in primary motor cortex (M1) exhibited an inhibitory phase-locking (2-5 ms) to the stimulus, an overall decrease in mean discharge rate, and an increase in response specificity to passive limb movement. Sub-therapeutic DBS (30 Hz) still produced entrainment to the stimulation, but the mean discharge rate and specificity to movement were not changed. Lower stimulation intensities (at 135 Hz), which no longer improved motor symptoms, had little effect on M1 activity. These findings suggest that DBS improves parkinsonian motor symptoms by inducing global changes in firing pattern and rate along the pallido-thalamocortical sensorimotor circuit.
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影响因子：
5.3
作者：
Xu, Weidong;Russo, Gary S.;Hashimoto, Takao;Zhang, Jianyu;Vitek, Jerrold L.
通讯作者：
Vitek, Jerrold L.
影响因子：
2.5
作者：
Boraud, T;Bezard, E;Gross, CE
通讯作者：
Gross, CE
影响因子：
14.5
作者：
Asanuma, Kotaro;Tang, Chengke;Eidelberg, David
通讯作者：
Eidelberg, David
影响因子：
5.3
作者：
Leblois, A;Boraud, T;Hansel, D
通讯作者：
Hansel, D
影响因子：
2.4
作者：
WATTS, RL;MANDIR, AS
通讯作者：
MANDIR, AS