Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions.
Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions.
复制标题
DOI：
10.1186/1471-2482-11-5
复制
发表时间：
2011-02-25
期刊：
影响因子：
1.9
通讯作者：
Li AW
中科院分区：
文献类型：
--
作者：
Zhang QY;Ma S;Xi D;Zhang WT;Li AW
粘连形成是一种重要的术后并发症。目前，还没有有效的方法来预防粘连形成，虽然屏障产品，如右旋糖酐（Dex）和透明质酸钠（SH）已被证明是最成功的临床，本研究旨在研究一种新的青霉胺结合膜的预防和治疗腹腔粘连形成的潜力。150只大鼠参与了本研究。将所有动物随机分为6组（1个溶媒组和5个试验组，分别用右旋糖酐、透明质酸钠、青霉胺、青霉胺结合膜或非青霉胺结合膜处理）。比较两组间腹腔粘连的发生率、粘连程度及评分。在媒介物组和青霉胺、具有/不具有青霉胺的膜处理组之间比较切口的断裂强度。比较溶剂组和青霉胺处理组之间I型胶原的表达。比较葡聚糖（Dex）、透明质酸钠（SH）、青霉胺处理组和含或不含青霉胺处理组之间的粘连发生率。青霉胺和青霉胺结合膜对腹腔粘连的预防作用明显优于右旋糖酐、透明质酸钠和非青霉胺结合膜。然而，它们都不影响切口愈合，尽管它们不显著地降低切口的断裂强度。与青霉胺相比，青霉胺结合膜具有更大的优势，可以更有效地局部载药。青霉胺结合膜可以作为一种有效的治疗干预腹部粘连的轻微副作用。
Adhesions formation is a significant postsurgical complication. At present, there is no effective method for preventing adhesions formation, although barrier products such as Dextran (Dex) and sodium hyaluronate (SH) have proved the most clinically successful, This study is designed to investigate the preventive and therapeutic potential of a novel penicillamine-bound membrane for abdominal adhesions formation. 150 rats were involved in the present study. All animals were randomly divided into 6 groups (1 vehicle group and 5 test groups respectively treated with dextran, sodium hyaluronate, penicillamine, penicillamine-bound membrane or non-penicillamine-bound membrane). The occurrence, grade and score of abdominal adhesions were compared between the different groups. The breaking strength of incision was compared between the vehicle group and the penicillamine, membrane with/without penicillamine - treated groups. Expression of collagen type I was compared between the vehicle and penicillamine-treated group. The occurrence of adhesions was compared between the Dextran (Dex), sodium hyaluronate (SH), penicillamine-treated group and membrane with or without penicillamine- treated groups. Penicillamine and penicillamine-bound membrane had significant preventive effects on abdominal adhesions formation, better than dextran, sodium hyaluronate and non-penicillamine-bound membrane. However, neither of them influenced incision healing, although they insignificantly decreased the breaking strength of the incision. Penicillamine-bound membrane, which can be loaded locally and more efficaciously, shows greater advantages than penicillamine. Penicillamine-bound membrane can be applied as an effective therapeutic intervention for abdominal adhesions with inconsequential side effects.
登录
查看更多内容
影响因子：
6
作者：
Gorvy, DA;Herrick, SE;Ferguson, MWJ
通讯作者：
Ferguson, MWJ
影响因子：
6.7
作者：
Nikeghbalian, Saman;Atefi, Sohrab;Jalaeian, Hamed
通讯作者：
Jalaeian, Hamed
DOI：
10.1007/bf01967800
发表时间：
1992-11-01
影响因子：
4.5
作者：
ROTSTEIN, OD
通讯作者：
ROTSTEIN, OD
影响因子：
168.9
作者：
HERBERT, CM;JAYSON, MIV;BAILEY, AJ
通讯作者：
BAILEY, AJ
影响因子：
3.4
作者：
van der Wal, J. B. C.;Jeekel, J.
通讯作者：
Jeekel, J.