Alcohol consumption and health status of family members: health impacts without ingestion.
Alcohol consumption and health status of family members: health impacts without ingestion.
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DOI：
10.1111/imj.12041
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发表时间：
2013-09
影响因子：
2.1
通讯作者：
Chikritzhs T
中科院分区：
文献类型：
--
作者：
Liang W;Chikritzhs T
几十年来，医学流行病学文献中的许多队列研究发现，与戒酒者相比，适度饮酒者患一系列疾病的风险较低。在观察性研究中，很难将适度饮酒的假设生理保护作用与其相关性良好的混杂因素分开。采用大规模的代表性一般人群调查，调查随机选择的家庭成员的当前酒精消费水平与生活在同一家庭中的其他成员的当前自我报告的健康状况之间的关联。Poisson回归模型，使用2008年，2009年和2010年全国健康访谈调查的数据，随机选择关键受访者饮酒量与同居家庭成员健康状况之间的关联。对随机选择的主要参与者的自我报告的酒精消费量和生活在同一家庭中的成人和儿童（父母报告）家庭成员的自我报告的健康状况进行了测量和比较。在控制了大量常见的混杂因素后，关键参与者的轻度和中度饮酒与其家庭成员（包括儿童）不良健康状况的患病率之间存在明显的负相关。归因于轻度和中度饮酒者的家庭成员的上级健康状况极有可能是虚假的，并且是由于残留的混淆而不是酒精的生理保护作用。未考虑的混杂因素可能会支持由于适度饮酒而产生的明显的“保护作用”，这些饮酒通常来自全因死亡率、心脏病、中风和其他慢性病的观察性研究。
Over several decades, many cohort studies from the medical epidemiology literature have observed that compared to abstainers, moderate drinkers experience lower risk for a range of diseases. It was very difficult to separate the hypothesised physiological protective effect of moderate drinking from its well correlated confounders in observational study settings. To investigate the association between current alcohol consumption levels of randomly selected family members and the current self-reported health status of other members living within the same family, using a large scale representative general population survey. Poisson regression models of the association between randomly selected key respondent alcohol consumption and health status of co-habiting family members using data from the 2008, 2009 and 2010 National Health Interview Surveys. Self-reported alcohol consumption of randomly selected key participants and self-reported health status of adult and child (parent reported) family members living in the same household were measured and compared. After controlling for a large range of commonly reported confounders, inverse associations were evident between light and moderate alcohol consumption of key participants and the prevalence of adverse health status among their family members, including children. The superior health status attributed to family members of light and moderate drinkers is highly likely to be spurious and due to residual confounding rather than physiologically protective effects of alcohol. Unaccounted for confounding is likely to underpin apparent ‘protective effects’ due to moderate drinking commonly reported from observational studies of all-cause mortality, heart disease, stroke, and other chronic diseases.
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影响因子：
5
作者：
Rehm J;Irving H;Ye Y;Kerr WC;Bond J;Greenfield TK
通讯作者：
Greenfield TK
影响因子：
7.2
作者：
Miilunpalo, S;Vuori, I;Urponen, H
通讯作者：
Urponen, H
影响因子：
5.4
作者：
Keil, U;Chambless, LE;Stieber, J
通讯作者：
Stieber, J
影响因子：
158.5
作者：
Stampfer, MJ;Kang, JH;Grodstein, F
通讯作者：
Grodstein, F
DOI：
10.1136/bmj.d671
发表时间：
2011-02-22
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Ronksley PE;Brien SE;Turner BJ;Mukamal KJ;Ghali WA
通讯作者：
Ghali WA