Effects of Solvents and pH Values on the Chemical Affinity of 10-Methacryloyloxydecyl Dihydrogen Phosphate toward Hydroxyapatite.
Effects of Solvents and pH Values on the Chemical Affinity of 10-Methacryloyloxydecyl Dihydrogen Phosphate toward Hydroxyapatite.
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DOI：
10.1021/acsomega.1c02521
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发表时间：
2021-07-27
期刊：
影响因子：
4.1
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Zhao Q;Han F;Yuan X;Chen C
研究了溶剂和pH值对10-甲基丙烯酰氧基癸基磷酸二氢酯（MDP）与羟基磷灰石（HAp）之间化学作用的影响。不同溶剂中MDP与HAp的化学亲和力（E-MDP：10重量% MDP和90重量%乙醇; E-W-MDP 1：10重量% MDP、75重量%乙醇和15重量%水; A-W-MDP：10重量% MDP、75重量%丙酮和15重量%水;和E-W-MDP 2：10重量% MDP、45重量%乙醇和45重量%水）。E-W-MDP 2的pH值从2.04升高至5（E-W-MDP 2/5）和7（E-W-MDP 2/7）。采用傅里叶变换红外光谱、X射线衍射（XRD）、X射线光电子能谱（XPS）、热重分析（TGA）和核磁共振（NMR）对反应产物进行了表征。XRD和NMR结果表明，E-MDP中没有形成MDP-钙盐。XRD、TGA和XPS结果表明，MDP与HAp发生相互作用，除E-MDP外，其余各组均生成MDP-钙盐。NMR结果表明，在E-W-MDP 1中形成了MDP二聚体（DCS-MD）和MDP三聚体（DCS-MT）的二钙盐以及MDP单体和MDP二聚体的一钙盐。在E-W-MDP 2和A-W-MDP中也形成了DCS-MD和DCS-MT。在E-W-MDP 2/5和E-W-MDP 2/7中，获得了DCS-MD。溶剂和pH值都影响MDP和HAp之间的化学相互作用以及形成的反应产物的类型。MDP和HAp在纯乙醇中不形成任何MDP-钙盐; MDP-钙盐的结构稳定性取决于溶剂水含量和pH值。建议将乙醇/水混合物作为含MDP底漆的主要溶剂，理想pH值为2-7;如果满足这些条件，预计将形成足够量的具有稳定结构的MDP-钙盐，从而提高牙本质/釉质粘结的寿命。
This study aimed to investigate the effects of solvents and pH values on the chemical interaction between 10-methacryloyloxydecyl dihydrogen phosphate (MDP) and hydroxyapatite (HAp). The chemical affinity of MDP toward HAp dissolved in different solvents (E-MDP: 10 wt % MDP and 90 wt % ethanol; E-W-MDP1: 10 wt % MDP, 75 wt % ethanol, and 15 wt % water; A-W-MDP: 10 wt % MDP, 75 wt % acetone, and 15 wt % water; and E-W-MDP2: 10 wt % MDP, 45 wt % ethanol, and 45 wt % water) was investigated. The pH of E-W-MDP2 was increased from 2.04 to 5 (E-W-MDP2/5) and to 7 (E-W-MDP2/7). The reaction products were characterized by Fourier transform infrared spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and nuclear magnetic resonance (NMR). XRD and NMR results revealed that no MDP-calcium salt formed in E-MDP. XRD, TGA, and XPS results indicated that MDP interacted with HAp, producing the MDP-calcium salt in all groups except E-MDP. NMR results revealed that the dicalcium salt of the MDP dimer (DCS-MD) and the MDP tripolymer (DCS-MT) and the monocalcium salt of the MDP monomer and the MDP dimer were formed in E-W-MDP1. DCS-MD and DCS-MT were also formed in E-W-MDP2 and A-W-MDP. In E-W-MDP2/5 and E-W-MDP2/7, DCS-MD was obtained. Both the solvents and pH values affect the chemical interactions between MDP and HAp and the types of reaction products formed. MDP and HAp do not form any MDP-calcium salt in pure ethanol; the structural stability of MDP-calcium salts is dependent on the solvent water content and the pH value. The ethanol/water mixture is recommended as the main solvent in an MDP-containing primer, and the ideal pH value is 2–7; if these conditions are satisfied, sufficient amounts of MDP-calcium salts with stable structures are expected to be formed, thus improving the longevity of dentin/enamel bonding.
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DOI：
10.1016/j.jmbbm.2020.103875
发表时间：
2020-10-01
影响因子：
3.9
作者：
Dressano, Diogo;Salvador, Marcos, V;Lima, Adriano Fonseca
通讯作者：
Lima, Adriano Fonseca
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影响因子：
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Chen, Ying;Lu, Zhicen;Tay, Franklin R.
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Tay, Franklin R.
影响因子：
5
作者：
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影响因子：
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作者：
Feitosa, V. P.;Ogliari, F. A.;Sauro, S.
通讯作者：
Sauro, S.
影响因子：
4.1
作者：
Han F;Dai S;Yang J;Shen J;Liao M;Xie H;Chen C
通讯作者：
Chen C