"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.
"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.
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DOI：
10.1016/j.vaccine.2017.04.007
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发表时间：
2017-06-14
期刊：
影响因子：
5.5
通讯作者：
Kornfeld H
中科院分区：
文献类型：
--
作者：
Boggiano C;Eichelberg K;Ramachandra L;Shea J;Ramakrishnan L;Behar S;Ernst JD;Porcelli SA;Maeurer M;Kornfeld H
结核病是世界各地传染病死亡的主要原因，特别是在感染艾滋病毒的人中。结核疫苗的设计和开发一直集中在改进卡介苗(BCG)和评估重组和病毒载体表达的结核分枝杆菌(Mtb)蛋白，以增强BCG诱导的免疫，但与BCG在预防感染或疾病方面的温和效果相比，这些方法尚未产生显著改善。2016年3月7日至8日，美国国家过敏症和传染病研究所(NIAID)召开了一次研讨会，主题是“结核分枝杆菌免疫逃避对保护性免疫的影响：对结核病疫苗设计的影响”，目的是通过新的研究方法确定可以针对的免疫机制，为预防结核病的疫苗设计和免疫治疗干预措施提供信息。研讨会讨论了早期感染事件、结核分枝杆菌进化对发展和维持适应性免疫反应的影响，以及影响预防和进展为活动性疾病的因素。会议讨论了振兴和加快结核病疫苗设计的科学差距和研究领域，并确定了优先事项。这些措施包括：全面评估疾病不同阶段肺部的先天和结核杆菌特异性适应性免疫反应；确定B细胞和抗体(Abs)在结核杆菌感染过程中的作用；开发更好的分析方法来衡量暴露、感染、潜伏和治疗后的结核杆菌负担，以及改进现有动物模型以研究结核杆菌的免疫原性、结核病疾病和传播的方法。
Tuberculosis (TB) is the major cause of death from infectious diseases around the world, particularly in HIV infected individuals. TB vaccine design and development have been focused on improving Bacille Calmette-Guérin (BCG) and evaluating recombinant and viral vector expressed Mycobacterium tuberculosis (Mtb) proteins, for boosting BCG-primed immunity, but these approaches have not yet yielded significant improvements over the modest effects of BCG in protecting against infection or disease. On March 7–8, 2016, the National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on “The Impact of Mtb Immune Evasion on Protective Immunity: Implications for TB Vaccine Design” with the goal of defining immune mechanisms that could be targeted through novel research approaches, to inform vaccine design and immune therapeutic interventions for prevention of TB. The workshop addressed early infection events, the impact of Mtb evolution on the development and maintenance of an adaptive immune response, and the factors that influence protection against and progression to active disease. Scientific gaps and areas of study to revitalize and accelerate TB vaccine design were discussed and prioritized. These included a comprehensive evaluation of innate and Mtb–specific adaptive immune responses in the lung at different stages of disease; determining the role of B cells and antibodies (Abs) during Mtb infection; development of better assays to measure Mtb burden following exposure, infection, during latency and after treatment, and approaches to improving current animal models to study Mtb immunogenicity, TB disease and transmission.
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结核分枝杆菌对抗原呈递的调节：Toll 样受体的作用。
DOI：
10.1038/nrmicro2321
发表时间：
2010-04
期刊：
Nature reviews. Microbiology
影响因子：
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作者：
通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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